Protein profile

KP13_01099

Ribosome-binding factor A

Genome: KpKP13

Gene: AHE42509.1 rbfA Structure source: AlphaFold + ColabFold UniProt A0A0H3GYX1
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Amino acids 133
Annotations 4
Features 15
PDB binders 0
Druggability 0.451

Overview

Basic information about this protein and its source genome.

Accession
KP13_01099
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42509.1 rbfA
Status
annotated
Amino acids
133
Structure source
AlphaFold + ColabFold
GO
GO:0006364 Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0043024 Binding to a small ribosomal subunit. GO:0030490 Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
97.744
DEG E-value
6.089999999999999e-94
Localization
Cytoplasmic
ColabFold pLDDT
81.71

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.451
Structure A0A0H3GYX1
Pocket Pocket 10
P2Rank
Structure A0A0H3GYX1
Pocket No pockets
ColabFold model
FPocket 0.442 · Pocket 6
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 148 / 4744 genomes with a hit
Normalized 0.031

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0006364 Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0043024 Binding to a small ribosomal subunit.
  • GO:0030490 Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
1 108 Gene3D G3DSA:3.30.300.20 -
1 108 InterPro IPR015946 K homology domain-like, alpha/beta
4 120 FunFam G3DSA:3.30.300.20:FF:000007 Ribosome-binding factor A
7 112 Pfam PF02033 Ribosome-binding factor A
7 112 InterPro IPR000238 Ribosome-binding factor A
4 130 PANTHER PTHR33515 RIBOSOME-BINDING FACTOR A, CHLOROPLASTIC-RELATED
4 130 InterPro IPR000238 Ribosome-binding factor A
6 113 Hamap MF_00003 Ribosome-binding factor A [rbfA].
6 113 InterPro IPR000238 Ribosome-binding factor A
1 119 NCBIfam TIGR00082 30S ribosome-binding factor RbfA
1 119 InterPro IPR000238 Ribosome-binding factor A
2 107 SUPERFAMILY SSF89919 Ribosome-binding factor A, RbfA
2 107 InterPro IPR023799 Ribosome-binding factor A domain superfamily
79 100 ProSitePatterns PS01319 Ribosome-binding factor A signature.
79 100 InterPro IPR020053 Ribosome-binding factor A, conserved site

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYX1
AlphaFold — — full sequence — Viewing
ColabFold KP13_01099
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
10 0.451