Protein profile

KP13_01094

Lipoprotein nlpI

Genome: KpKP13

Gene: nlpI AHE42513.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYW7
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Amino acids 294
Annotations 4
Features 30
PDB binders 0
Druggability 0.382

Overview

Basic information about this protein and its source genome.

Accession
KP13_01094
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
nlpI AHE42513.1
Status
annotated
Amino acids
294
Structure source
AlphaFold + ColabFold
GO
GO:0005515 Binding to a protein. GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046813 The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
92.6

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.382
Structure A0A0H3GYW7
Pocket Pocket 9
P2Rank 0.427
Structure A0A0H3GYW7
Pocket Pocket 1
ColabFold model
FPocket 0.388 · Pocket 11
P2Rank 0.279 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 123 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005515 Binding to a protein.
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0046813 The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface.

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records
Show feature table
Start End DB Term Name
27 283 SUPERFAMILY SSF48452 TPR-like
27 283 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
20 294 FunFam G3DSA:1.25.40.10:FF:000021 Lipoprotein NlpI
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region
18 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
63 171 PANTHER PTHR44858 TETRATRICOPEPTIDE REPEAT PROTEIN 6
62 94 Pfam PF13181 Tetratricopeptide repeat
62 94 InterPro IPR019734 Tetratricopeptide repeat
26 294 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
173 196 Coils Coil Coil
1 25 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 19 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
62 95 ProSiteProfiles PS50005 TPR repeat profile.
62 95 InterPro IPR019734 Tetratricopeptide repeat
96 129 ProSiteProfiles PS50005 TPR repeat profile.
96 129 InterPro IPR019734 Tetratricopeptide repeat
1 19 SignalP_EUK SignalP-noTM SignalP-noTM
20 294 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
20 294 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
96 129 Pfam PF07719 Tetratricopeptide repeat
96 129 InterPro IPR013105 Tetratricopeptide repeat 2
1 25 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
7 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 292 PIRSF PIRSF004654 NlpI
1 292 InterPro IPR023605 Lipoprotein NlpI
234 267 SMART SM00028 tpr_5
234 267 InterPro IPR019734 Tetratricopeptide repeat
96 129 SMART SM00028 tpr_5
62 95 SMART SM00028 tpr_5

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYW7
AlphaFold — — full sequence — Viewing
ColabFold KP13_01094
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
9 0.382
12 0.326

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.73 0.576
2 1.74 0.031
3 1.6 0.025
4 1.49 0.021