Protein profile

KP13_01092

Tryptophan-specific transport protein

Genome: KpKP13

Gene: mtr AHE42515.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H3G8

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Amino acids 414

Annotations 4

Features 62

PDB binders 0

Druggability 0.95

Overview

Basic information about this protein and its source genome.

Accession: KP13_01092
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: mtr AHE42515.1
Status: annotated
Amino acids: 414
Structure source: AlphaFold + ColabFold

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015801 The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0003333 The process in which an amino acid is transported across a membrane. GO:0015173 Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 51.843
DEG E-value: 1.6e-142
Localization: CytoplasmicMembrane
ColabFold pLDDT: 89.12

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.95

Structure A0A0H3H3G8

Pocket Pocket 21

P2Rank 0.954

Structure A0A0H3H3G8

Pocket Pocket 1

ColabFold model

FPocket 0.746 · Pocket 5

P2Rank 0.95 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 123 / 4744 genomes with a hit

Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0015801 The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0003333 The process in which an amino acid is transported across a membrane.
GO:0015173 Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring.

Sequence Features

Domain/signature hits from InterPro and related databases.

62 records

Show feature table

Start	End	DB	Term	Name
171	189	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
208	227	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
319	336	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
379	404	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
13	35	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
228	246	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
86	107	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
10	413	FunFam	G3DSA:1.20.1740.10:FF:000019	Tryptophan permease TnaB
381	403	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
39	61	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
368	378	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
87	109	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
284	309	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
284	306	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
146	151	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
346	368	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
405	414	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
127	145	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
66	85	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
155	175	PRINTS	PR00166	Aromatic amino acid permease signature
155	175	InterPro	IPR013059	Tryptophan/tyrosine transporter
45	64	PRINTS	PR00166	Aromatic amino acid permease signature
45	64	InterPro	IPR013059	Tryptophan/tyrosine transporter
232	251	PRINTS	PR00166	Aromatic amino acid permease signature
232	251	InterPro	IPR013059	Tryptophan/tyrosine transporter
293	312	PRINTS	PR00166	Aromatic amino acid permease signature
293	312	InterPro	IPR013059	Tryptophan/tyrosine transporter
348	367	PRINTS	PR00166	Aromatic amino acid permease signature
348	367	InterPro	IPR013059	Tryptophan/tyrosine transporter
18	41	PRINTS	PR00166	Aromatic amino acid permease signature
18	41	InterPro	IPR013059	Tryptophan/tyrosine transporter
90	110	PRINTS	PR00166	Aromatic amino acid permease signature
90	110	InterPro	IPR013059	Tryptophan/tyrosine transporter
193	215	PRINTS	PR00166	Aromatic amino acid permease signature
193	215	InterPro	IPR013059	Tryptophan/tyrosine transporter
327	345	PRINTS	PR00166	Aromatic amino acid permease signature
327	345	InterPro	IPR013059	Tryptophan/tyrosine transporter
12	34	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
310	320	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
190	212	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
345	367	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
340	344	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
129	146	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
153	175	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
10	402	Pfam	PF03222	Tryptophan/tyrosine permease family
10	402	InterPro	IPR018227	Amino acid/polyamine transporter 2
40	65	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
7	414	PANTHER	PTHR46997	LOW AFFINITY TRYPTOPHAN PERMEASE-RELATED
7	414	InterPro	IPR013059	Tryptophan/tyrosine transporter
190	207	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
225	247	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
108	126	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	11	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
321	339	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
152	170	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
10	413	Gene3D	G3DSA:1.20.1740.10	Amino acid/polyamine transporter I
247	283	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
15	395	NCBIfam	TIGR00837	aromatic amino acid transporter
15	395	InterPro	IPR013059	Tryptophan/tyrosine transporter
35	39	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
25	41	ProSitePatterns	PS00594	Aromatic amino acids permeases signature.
25	41	InterPro	IPR013061	Tryptophan/tryrosine permease, conserved site

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3H3G8	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_01092	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
21				0.95
2				0.53

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	26.5	0.914
2	9.54	0.513
3	5.7	0.276
4	4.52	0.193
5	2.48	0.068

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
5				0.746
22				0.497

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	26.51	0.914
2	10.57	0.568
3	4.55	0.195
4	3.96	0.157
5	3.03	0.1