Protein profile

KP13_01089

putative protease

Genome: KpKP13

Gene: AHE42518.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYW0
Export view
Amino acids 331
Annotations 3
Features 9
PDB binders 0
Druggability 0.799

Overview

Basic information about this protein and its source genome.

Accession
KP13_01089
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42518.1
Status
annotated
Amino acids
331
Structure source
AlphaFold + ColabFold
GO
GO:0006744 The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
94.4

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.799
Structure A0A0H3GYW0
Pocket Pocket 3
P2Rank 0.881
Structure A0A0H3GYW0
Pocket Pocket 1
ColabFold model
FPocket 0.457 · Pocket 6
P2Rank 0.938 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 146 / 4744 genomes with a hit
Normalized 0.031

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006744 The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
  • GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
1 331 PANTHER PTHR30217 PEPTIDASE U32 FAMILY
11 162 SUPERFAMILY SSF51391 Thiamin phosphate synthase
11 162 InterPro IPR036206 Thiamin phosphate synthase superfamily
161 179 ProSitePatterns PS01276 Peptidase family U32 signature.
161 179 InterPro IPR001539 Peptidase U32
76 330 Pfam PF01136 Peptidase family U32
76 330 InterPro IPR001539 Peptidase U32
1 331 Hamap MF_02232 Ubiquinone biosynthesis protein UbiU [ubiU].
1 331 InterPro IPR043692 Ubiquinone biosynthesis protein UbiU

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYW0
AlphaFold — — full sequence — Viewing
ColabFold KP13_01089
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.799

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.49 0.564
2 8.98 0.481
3 1.7 0.03
4 0.68 0.001