Protein profile

KP13_01088

SCP2 sterol-binding domain-containing protein

Genome: KpKP13

Gene: AHE42519.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTN4
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Amino acids 173
Annotations 2
Features 13
PDB binders 0
Druggability 0.965

Overview

Basic information about this protein and its source genome.

Accession
KP13_01088
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42519.1
Status
annotated
Amino acids
173
Structure source
AlphaFold + ColabFold
GO
GO:0006744 The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
86.64

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.965
Structure A0A0H3GTN4
Pocket Pocket 2
P2Rank 0.928
Structure A0A0H3GTN4
Pocket Pocket 1
ColabFold model
FPocket 0.93 · Pocket 2
P2Rank 0.891 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 115 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0006744 The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
57 134 Gene3D G3DSA:3.30.1050.10 -
57 134 InterPro IPR036527 SCP2 sterol-binding domain superfamily
1 139 PANTHER PTHR10094 STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN
1 139 InterPro IPR039543 Lipid-binding protein POX18/UbiT/NSL-TP1
10 136 Hamap MF_02231 Ubiquinone biosynthesis accessory factor UbiT [ubiT].
10 136 InterPro IPR016830 Ubiquinone biosynthesis accessory factor UbiT
43 137 FunFam G3DSA:3.30.1050.10:FF:000002 SCP2 domain-containing protein YhbT
43 132 Pfam PF02036 SCP-2 sterol transfer family
43 132 InterPro IPR003033 SCP2 sterol-binding domain
42 136 SUPERFAMILY SSF55718 SCP-like
42 136 InterPro IPR036527 SCP2 sterol-binding domain superfamily
1 172 PIRSF PIRSF025550 UCP025550_lpd_carrier
1 172 InterPro IPR016830 Ubiquinone biosynthesis accessory factor UbiT

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTN4
AlphaFold — — full sequence — Viewing
ColabFold KP13_01088
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.965

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 30.02 0.933
2 1.55 0.023