Protein profile

KP13_01087

putative N-acetyltransferase

Genome: KpKP13

Gene: AHE42520.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H3G3
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Amino acids 163
Annotations 1
Features 10
PDB binders 0
Druggability 0.622

Overview

Basic information about this protein and its source genome.

Accession
KP13_01087
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42520.1
Status
annotated
Amino acids
163
Structure source
AlphaFold + ColabFold
GO
GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
81.595
DEG E-value
2.41e-94
Localization
Cytoplasmic
ColabFold pLDDT
96.99

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.622
Structure A0A0H3H3G3
Pocket Pocket 1
P2Rank 0.315
Structure A0A0H3H3G3
Pocket Pocket 1
ColabFold model
FPocket 0.313 · Pocket 6
P2Rank 0.236 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 116 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
4 163 Gene3D G3DSA:3.40.630.30 -
6 159 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
6 159 InterPro IPR016181 Acyl-CoA N-acyltransferase
41 120 Pfam PF13508 Acetyltransferase (GNAT) domain
41 120 InterPro IPR000182 GNAT domain
1 144 ProSiteProfiles PS51186 Gcn5-related N-acetyltransferase (GNAT) domain profile.
1 144 InterPro IPR000182 GNAT domain
40 105 CDD cd04301 NAT_SF
1 163 FunFam G3DSA:3.40.630.30:FF:000008 Acetyltransferase, GNAT family
22 131 PANTHER PTHR43617 L-AMINO ACID N-ACETYLTRANSFERASE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H3G3
AlphaFold — — full sequence — Viewing
ColabFold KP13_01087
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
17 0.01
4 0.001
7 0.001
19 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.21 0.315
2 5.24 0.201