Protein profile

KP13_01086

putative excinuclease ABC

Genome: KpKP13

Gene: AHE42521.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GW33
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Amino acids 105
Annotations 0
Features 13
PDB binders 0
Druggability 0.234

Overview

Basic information about this protein and its source genome.

Accession
KP13_01086
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42521.1
Status
annotated
Amino acids
105
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
74.444
DEG E-value
3.52e-43
Localization
Cytoplasmic
ColabFold pLDDT
88.73

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.234
Structure A0A0H3GW33
Pocket Pocket 1
P2Rank 0.004
Structure A0A0H3GW33
Pocket Pocket 1
ColabFold model
FPocket 0.448 · Pocket 3
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 119 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
92 105 Coils Coil Coil
11 102 Hamap MF_01029 UPF0213 protein YhbQ [yhbQ].
11 102 InterPro IPR022992 Uncharacterised protein family UPF0213, GIY-YIG endonuclease
14 83 SUPERFAMILY SSF82771 GIY-YIG endonuclease
14 83 InterPro IPR035901 GIY-YIG endonuclease superfamily
12 87 ProSiteProfiles PS50164 GIY-YIG domain profile.
12 87 InterPro IPR000305 GIY-YIG endonuclease
11 103 Gene3D G3DSA:3.40.1440.10 -
11 103 InterPro IPR035901 GIY-YIG endonuclease superfamily
13 99 PANTHER PTHR34477 UPF0213 PROTEIN YHBQ
14 81 CDD cd10456 GIY-YIG_UPF0213
13 84 Pfam PF01541 GIY-YIG catalytic domain
13 84 InterPro IPR000305 GIY-YIG endonuclease

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GW33
AlphaFold — — full sequence — Viewing
ColabFold KP13_01086
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.234