Protein profile

KP13_01077

Ribosomal RNA small subunit methyltransferase I

Genome: KpKP13

Gene: AHE42530.1 rsmI Structure source: AlphaFold + ColabFold UniProt A0A0H3H3F4
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Amino acids 287
Annotations 1
Features 22
PDB binders 0
Druggability 0.666

Overview

Basic information about this protein and its source genome.

Accession
KP13_01077
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42530.1 rsmI
Status
annotated
Amino acids
287
Structure source
AlphaFold + ColabFold
GO
GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
93.706
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
93.79

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.666
Structure A0A0H3H3F4
Pocket Pocket 1
P2Rank 0.506
Structure A0A0H3H3F4
Pocket Pocket 1
ColabFold model
FPocket 0.681 · Pocket 1
P2Rank 0.385 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 265 / 4744 genomes with a hit
Normalized 0.056

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
121 241 Gene3D G3DSA:3.30.950.10 -
121 241 InterPro IPR014776 Tetrapyrrole methylase, subdomain 2
1 287 PIRSF PIRSF005917 MTase_YraL
1 287 InterPro IPR008189 rRNA small subunit methyltransferase I
15 233 CDD cd11648 RsmI
15 233 InterPro IPR008189 rRNA small subunit methyltransferase I
91 102 ProSitePatterns PS01296 RsmI AdoMet-dependent methyltransferase protein family signature.
91 102 InterPro IPR018063 SAM-dependent methyltransferase RsmI, conserved site
13 234 Hamap MF_01877 Ribosomal RNA small subunit methyltransferase I [rsmI].
13 234 InterPro IPR008189 rRNA small subunit methyltransferase I
1 120 FunFam G3DSA:3.40.1010.10:FF:000002 Ribosomal RNA small subunit methyltransferase I
14 213 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases
14 213 InterPro IPR000878 Tetrapyrrole methylase
14 283 NCBIfam TIGR00096 16S rRNA (cytidine(1402)-2'-O)-methyltransferase
14 283 InterPro IPR008189 rRNA small subunit methyltransferase I
10 286 PANTHER PTHR46111 RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I
10 286 InterPro IPR008189 rRNA small subunit methyltransferase I
12 232 SUPERFAMILY SSF53790 Tetrapyrrole methylase
12 232 InterPro IPR035996 Tetrapyrrole methylase superfamily
1 120 Gene3D G3DSA:3.40.1010.10 -
1 120 InterPro IPR014777 Tetrapyrrole methylase, subdomain 1
121 240 FunFam G3DSA:3.30.950.10:FF:000002 Ribosomal RNA small subunit methyltransferase I

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H3F4
AlphaFold — — full sequence — Viewing
ColabFold KP13_01077
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.666

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.64 0.404