Protein profile

KP13_02877

hypothetical protein

Genome: KpKP13

Gene: AHE42553.1 Structure source: Experimental + ColabFold UniProt A6TED5
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Amino acids 128
Annotations 0
Features 11
PDB binders 0
Druggability 0.53

Overview

Basic information about this protein and its source genome.

Accession
KP13_02877
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42553.1
Status
annotated
Amino acids
128
Structure source
Experimental + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
60.63
DEG E-value
1.27e-46
Localization
CytoplasmicMembrane
ColabFold pLDDT
81.84

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.53
Structure 4PWU
Pocket Pocket 8
P2Rank
Structure 4PWU
Pocket No pockets
ColabFold model
FPocket 0.465 · Pocket 4
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 63 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
3 117 Hamap MF_00904 Modulator protein MzrA [mzrA].
3 117 InterPro IPR026574 Modulator protein MzrA
31 34 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
21 106 Pfam PF13721 SecD export protein N-terminal TM region
21 106 InterPro IPR027398 SecD export protein N-terminal TM domain
35 128 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 14 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 34 Phobius SIGNAL_PEPTIDE Signal peptide region
31 111 Gene3D G3DSA:3.30.70.260 -
12 31 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
15 30 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4PWU
X-ray 20.00 Å - —
PDBe RCSB PDBj File
Viewing
ColabFold KP13_02877
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.104
2 0.031
4 0.02
3 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.96 0.096
2 1.97 0.042
3 1.41 0.018
4 1.26 0.012