Protein profile

KP13_02875

Exu regulon transcriptional regulator

Genome: KpKP13

Gene: AHE42555.1 exuR Structure source: AlphaFold + ColabFold UniProt A0A0H3GVZ9
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Amino acids 258
Annotations 3
Features 26
PDB binders 0
Druggability 0.848

Overview

Basic information about this protein and its source genome.

Accession
KP13_02875
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42555.1 exuR
Status
annotated
Amino acids
258
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
84.39

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.848
Structure A0A0H3GVZ9
Pocket Pocket 14
P2Rank 0.093
Structure A0A0H3GVZ9
Pocket Pocket 1
ColabFold model
FPocket 0.386 · Pocket 19
P2Rank 0.527 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 102 / 4744 genomes with a hit
Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
96 220 SMART SM00895 FCD_2
96 220 InterPro IPR011711 GntR, C-terminal
94 226 SUPERFAMILY SSF48008 GntR ligand-binding domain-like
94 226 InterPro IPR008920 Transcription regulator FadR/GntR, C-terminal
3 77 Gene3D G3DSA:1.10.10.10 -
3 77 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
3 231 PANTHER PTHR43537 TRANSCRIPTIONAL REGULATOR, GNTR FAMILY
7 75 ProSiteProfiles PS50949 GntR-type HTH domain profile.
7 75 InterPro IPR000524 Transcription regulator HTH, GntR
13 72 SMART SM00345 gntr3
13 72 InterPro IPR000524 Transcription regulator HTH, GntR
2 76 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
2 76 InterPro IPR036390 Winged helix DNA-binding domain superfamily
46 62 PRINTS PR00035 GntR bacterial regulatory protein HTH signature
46 62 InterPro IPR000524 Transcription regulator HTH, GntR
32 46 PRINTS PR00035 GntR bacterial regulatory protein HTH signature
32 46 InterPro IPR000524 Transcription regulator HTH, GntR
95 229 Gene3D G3DSA:1.20.120.530 -
95 229 InterPro IPR008920 Transcription regulator FadR/GntR, C-terminal
96 219 Pfam PF07729 FCD domain
96 219 InterPro IPR011711 GntR, C-terminal
9 72 Pfam PF00392 Bacterial regulatory proteins, gntR family
9 72 InterPro IPR000524 Transcription regulator HTH, GntR
95 229 FunFam G3DSA:1.20.120.530:FF:000002 GntR family transcriptional regulator
9 69 CDD cd07377 WHTH_GntR
9 69 InterPro IPR000524 Transcription regulator HTH, GntR

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVZ9
AlphaFold — — full sequence — Viewing
ColabFold KP13_02875
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
14 0.848

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.7 0.081
2 2.0 0.043
3 1.93 0.039
4 1.44 0.019