Protein profile

KP13_02873

Uronate isomerase

Genome: KpKP13

Gene: AHE42558.1 uxaC Structure source: AlphaFold + ColabFold UniProt A0A0H3GYR8
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Amino acids 470
Annotations 5
Features 10
PDB binders 0
Druggability 0.414

Overview

Basic information about this protein and its source genome.

Accession
KP13_02873
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42558.1 uxaC
Status
annotated
Amino acids
470
Structure source
AlphaFold + ColabFold
EC
5.3.1.12
GO
GO:0006064 The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid. GO:0008880 Catalysis of the reaction: D-glucuronate = D-fructuronate. Also converts D-galacturonate to D-tagaturonate. GO:0019698 The chemical reactions and pathways resulting in the breakdown of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid. GO:0042840 The chemical reactions and pathways resulting in the breakdown of D-glucuronate, the D-enantiomer of glucuronate.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
97.73

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.414
Structure A0A0H3GYR8
Pocket Pocket 8
P2Rank 0.867
Structure A0A0H3GYR8
Pocket Pocket 1
ColabFold model
FPocket 0.373 · Pocket 2
P2Rank 0.853 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 853 / 4744 genomes with a hit
Normalized 0.18

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0006064 The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid.
  • GO:0008880 Catalysis of the reaction: D-glucuronate = D-fructuronate. Also converts D-galacturonate to D-tagaturonate.
  • GO:0019698 The chemical reactions and pathways resulting in the breakdown of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid.
  • GO:0042840 The chemical reactions and pathways resulting in the breakdown of D-glucuronate, the D-enantiomer of glucuronate.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
46 139 Gene3D G3DSA:1.10.2020.10 uronate isomerase, domain 2, chain A
1 465 Pfam PF02614 Glucuronate isomerase
1 465 InterPro IPR003766 Uronate isomerase
3 465 SUPERFAMILY SSF51556 Metallo-dependent hydrolases
3 465 InterPro IPR032466 Metal-dependent hydrolase
2 467 Hamap MF_00675 Uronate isomerase [uxaC].
2 467 InterPro IPR003766 Uronate isomerase
1 467 PANTHER PTHR30068 URONATE ISOMERASE
46 139 FunFam G3DSA:1.10.2020.10:FF:000001 Uronate isomerase
7 458 Gene3D G3DSA:3.20.20.140 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYR8
AlphaFold — — full sequence — Viewing
ColabFold KP13_02873
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.414
3 0.319
26 0.24

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 19.26 0.837
2 2.6 0.075
3 1.95 0.041
4 1.72 0.03
5 1.2 0.011