Protein profile

KP13_02865

B3/B4 domain-containing protein

Genome: KpKP13

Gene: AHE42566.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GVY9
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Amino acids 235
Annotations 2
Features 8
PDB binders 0
Druggability 0.698

Overview

Basic information about this protein and its source genome.

Accession
KP13_02865
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42566.1
Status
annotated
Amino acids
235
Structure source
AlphaFold + ColabFold
GO
GO:0004826 Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). GO:0003723 Binding to an RNA molecule or a portion thereof.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
95.04

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.698
Structure A0A0H3GVY9
Pocket Pocket 2
P2Rank 0.478
Structure A0A0H3GVY9
Pocket Pocket 1
ColabFold model
FPocket 0.738 · Pocket 2
P2Rank 0.564 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 53 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0004826 Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).
  • GO:0003723 Binding to an RNA molecule or a portion thereof.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
65 198 Gene3D G3DSA:3.50.40.10 -
65 198 InterPro IPR020825 Phenylalanyl-tRNA synthetase-like, B3/B4
11 226 PANTHER PTHR39209 -
50 225 SUPERFAMILY SSF56037 PheT/TilS domain
61 217 SMART SM00873 B3_4_2
61 217 InterPro IPR005146 B3/B4 tRNA-binding domain
63 191 Pfam PF03483 B3/4 domain
63 191 InterPro IPR005146 B3/B4 tRNA-binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVY9
AlphaFold — — full sequence — Viewing
ColabFold KP13_02865
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.698
5 0.294
3 0.278

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.84 0.285