Protein profile

KP13_02855

Autoinducer 2-degrading protein lsrG

Genome: KpKP13

Gene: lsrG AHE42576.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GVX3
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Amino acids 93
Annotations 4
Features 9
PDB binders 0
Druggability 0.133

Overview

Basic information about this protein and its source genome.

Accession
KP13_02855
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
lsrG AHE42576.1
Status
annotated
Amino acids
93
Structure source
AlphaFold + ColabFold
EC
5.3.1.32
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0002952 Catalysis of the reaction: (2S)-2-hydroxy-3,4-dioxopentyl phosphate = 3-hydroxy-2,4-dioxopentyl phosphate. GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
96.87

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.133
Structure A0A0H3GVX3
Pocket Pocket 1
P2Rank 0.438
Structure A0A0H3GVX3
Pocket Pocket 1
ColabFold model
FPocket 0.108 · Pocket 4
P2Rank 0.353 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 61 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0002952 Catalysis of the reaction: (2S)-2-hydroxy-3,4-dioxopentyl phosphate = 3-hydroxy-2,4-dioxopentyl phosphate.
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
1 91 FunFam G3DSA:3.30.70.100:FF:000016 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase
2 71 Pfam PF03992 Antibiotic biosynthesis monooxygenase
2 71 InterPro IPR007138 Antibiotic biosynthesis monooxygenase domain
1 93 Gene3D G3DSA:3.30.70.100 -
2 84 PANTHER PTHR33336 QUINOL MONOOXYGENASE YGIN-RELATED
2 86 SUPERFAMILY SSF54909 Dimeric alpha+beta barrel
2 86 InterPro IPR011008 Dimeric alpha-beta barrel
1 86 ProSiteProfiles PS51725 ABM domain profile.
1 86 InterPro IPR007138 Antibiotic biosynthesis monooxygenase domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVX3
AlphaFold — — full sequence — Viewing
ColabFold KP13_02855
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.23 0.376