Protein profile

KP13_02853

putative HTH-type transcriptional regulator

Genome: KpKP13

Gene: AHE42578.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYP6
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Amino acids 184
Annotations 0
Features 9
PDB binders 0
Druggability 0.875

Overview

Basic information about this protein and its source genome.

Accession
KP13_02853
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42578.1
Status
annotated
Amino acids
184
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
81.84

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.875
Structure A0A0H3GYP6
Pocket Pocket 1
P2Rank
Structure A0A0H3GYP6
Pocket No pockets
ColabFold model
FPocket 0.502 · Pocket 5
P2Rank 0.008 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 63 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
30 133 Gene3D G3DSA:1.10.10.10 -
30 133 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
41 166 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
41 166 InterPro IPR036390 Winged helix DNA-binding domain superfamily
1 33 MobiDBLite mobidb-lite consensus disorder prediction
10 33 MobiDBLite mobidb-lite consensus disorder prediction
35 182 PANTHER PTHR43252 TRANSCRIPTIONAL REGULATOR YQJI
45 101 Pfam PF03551 Transcriptional regulator PadR-like family
45 101 InterPro IPR005149 Transcription regulator PadR, N-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYP6
AlphaFold — — full sequence — Viewing
ColabFold KP13_02853
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.875
2 0.205