Protein profile

KP13_02852

putative siderophore-interacting protein

Genome: KpKP13

Gene: AHE42579.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H3A8
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Amino acids 258
Annotations 1
Features 15
PDB binders 0
Druggability 0.19

Overview

Basic information about this protein and its source genome.

Accession
KP13_02852
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42579.1
Status
annotated
Amino acids
258
Structure source
AlphaFold + ColabFold
GO
GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
94.51

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.19
Structure A0A0H3H3A8
Pocket Pocket 19
P2Rank 0.815
Structure A0A0H3H3A8
Pocket Pocket 1
ColabFold model
FPocket 0.591 · Pocket 4
P2Rank 0.895 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 69 / 4744 genomes with a hit
Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
25 135 Pfam PF08021 Siderophore-interacting FAD-binding domain
25 135 InterPro IPR013113 FAD-binding 9, siderophore-interacting
25 255 CDD cd06193 siderophore_interacting
9 140 SUPERFAMILY SSF63380 Riboflavin synthase domain-like
9 140 InterPro IPR017938 Riboflavin synthase-like beta-barrel
8 136 FunFam G3DSA:2.40.30.10:FF:000055 Siderophore-interacting family protein
13 257 PANTHER PTHR30157 FERRIC REDUCTASE, NADPH-DEPENDENT
13 257 InterPro IPR039374 Siderophore-interacting protein
137 258 Gene3D G3DSA:3.40.50.80 -
137 258 InterPro IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
18 139 ProSiteProfiles PS51384 Ferredoxin reductase-type FAD binding domain profile.
18 139 InterPro IPR017927 FAD-binding domain, ferredoxin reductase-type
143 257 Pfam PF04954 Siderophore-interacting protein
143 257 InterPro IPR007037 Siderophore-interacting protein, C-terminal domain
6 136 Gene3D G3DSA:2.40.30.10 Translation factors

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H3A8
AlphaFold — — full sequence — Viewing
ColabFold KP13_02852
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.33 0.647
2 1.26 0.012