Protein profile

KP13_02849

PTS-dependent dihydroxyacetone kinase, ADP-binding subunit dhaL

Genome: KpKP13

Gene: dhaL AHE42582.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYP2
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Amino acids 210
Annotations 5
Features 14
PDB binders 0
Druggability 0.761

Overview

Basic information about this protein and its source genome.

Accession
KP13_02849
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
dhaL AHE42582.1
Status
annotated
Amino acids
210
Structure source
AlphaFold + ColabFold
GO
GO:0004371 Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+. GO:0006071 The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. GO:0016772 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019563 The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
32.418
Human E-value
4.49e-12
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
83.333
DEG E-value
2.64e-127
Localization
Cytoplasmic
ColabFold pLDDT
97.85

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.761
Structure A0A0H3GYP2
Pocket Pocket 1
P2Rank 0.886
Structure A0A0H3GYP2
Pocket Pocket 1
ColabFold model
FPocket 0.657 · Pocket 1
P2Rank 0.84 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 69 / 4744 genomes with a hit
Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0004371 Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+.
  • GO:0006071 The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.
  • GO:0016772 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0019563 The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
33 205 Pfam PF02734 DAK2 domain
33 205 InterPro IPR004007 DhaL domain
20 208 PANTHER PTHR28629 TRIOKINASE/FMN CYCLASE
4 209 FunFam G3DSA:1.25.40.340:FF:000002 Dihydroxyacetone kinase, L subunit
2 205 SUPERFAMILY SSF101473 DhaL-like
2 205 InterPro IPR036117 DhaL domain superfamily
32 206 SMART SM01120 Dak2_2
32 206 InterPro IPR004007 DhaL domain
1 210 Gene3D G3DSA:1.25.40.340 -
1 210 InterPro IPR036117 DhaL domain superfamily
6 206 ProSiteProfiles PS51480 DhaL domain profile.
6 206 InterPro IPR004007 DhaL domain
9 205 NCBIfam TIGR02365 dihydroxyacetone kinase subunit DhaL
9 205 InterPro IPR012737 Dihydroxyacetone kinase, subunit L

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYP2
AlphaFold — — full sequence — Viewing
ColabFold KP13_02849
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.761

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 14.64 0.729
2 1.63 0.027