Protein profile

KP13_02838

glycerol dehydratase medium subunit

Genome: KpKP13

Gene: dhaC AHE42593.1 Structure source: Experimental + ColabFold UniProt O08505
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Amino acids 194
Annotations 4
Features 8
PDB binders 0
Druggability 0.803

Overview

Basic information about this protein and its source genome.

Accession
KP13_02838
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
dhaC AHE42593.1
Status
annotated
Amino acids
194
Structure source
Experimental + ColabFold
EC
4.2.1.30 4.2.1.28
GO
GO:0046405 Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O. GO:0050215 Catalysis of the reaction: propane-1,2-diol = H2O + propanal.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
95.24

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.803
Structure 1IWP
Pocket Pocket 1
P2Rank 0.231
Structure 1IWP
Pocket Pocket 1
ColabFold model
FPocket 0.459 · Pocket 1
P2Rank 0.125 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 186 / 4744 genomes with a hit
Normalized 0.039

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 EC 2 GO

Enzyme Commission (EC)

2

Gene Ontology (GO)

2
  • GO:0046405 Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O.
  • GO:0050215 Catalysis of the reaction: propane-1,2-diol = H2O + propanal.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
13 193 SUPERFAMILY SSF52968 B12-dependent dehydatase associated subunit
13 193 InterPro IPR010254 B12-dependent dehydratases, beta subunit
1 194 Gene3D G3DSA:3.40.50.10150 -
1 194 InterPro IPR010254 B12-dependent dehydratases, beta subunit
2 191 PIRSF PIRSF018506 Prpndl_dhdrts_md
2 191 InterPro IPR025541 Propanediol/glycerol dehydratase, medium subunit
36 148 Pfam PF02288 Dehydratase medium subunit
36 148 InterPro IPR003208 Diol/glycerol dehydratase/dehydratase reactivating factor

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 1IWP
X-ray 2.10 Å B,E
100.0% 1-194
PDBe RCSB PDBj File
Viewing
PDB 1MMF
X-ray 2.50 Å B,E
100.0% 1-194
PDBe RCSB PDBj File
Loaded
ColabFold KP13_02838
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.971
2 0.906
5 0.663
11 0.496

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 42.62 0.968
2 42.49 0.968
3 15.76 0.761
4 14.89 0.738
5 9.62 0.517