Protein profile

KP13_02837

glycerol dehydratase small subunit

Genome: KpKP13

Gene: AHE42594.1 dhaE Structure source: Experimental + ColabFold UniProt Q59475
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Amino acids 141
Annotations 4
Features 8
PDB binders 0
Druggability 0.695

Overview

Basic information about this protein and its source genome.

Accession
KP13_02837
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42594.1 dhaE
Status
annotated
Amino acids
141
Structure source
Experimental + ColabFold
EC
4.2.1.30 4.2.1.28
GO
GO:0046405 Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O. GO:0050215 Catalysis of the reaction: propane-1,2-diol = H2O + propanal.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
95.85

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.695
Structure 1MMF
Pocket Pocket 1
P2Rank 0.092
Structure 1IWP
Pocket Pocket 1
ColabFold model
FPocket 0.314 · Pocket 7
P2Rank 0.03 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 100 / 4744 genomes with a hit
Normalized 0.021

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 EC 2 GO

Enzyme Commission (EC)

2

Gene Ontology (GO)

2
  • GO:0046405 Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O.
  • GO:0050215 Catalysis of the reaction: propane-1,2-diol = H2O + propanal.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
7 138 Pfam PF02287 Dehydratase small subunit
7 138 InterPro IPR003207 Propanediol/glycerol dehydratase, small subunit
1 141 PIRSF PIRSF018505 Prpndl_dhdrts_sm
1 141 InterPro IPR003207 Propanediol/glycerol dehydratase, small subunit
4 139 SUPERFAMILY SSF47148 Diol dehydratase, gamma subunit
4 139 InterPro IPR036091 Propanediol/glycerol dehydratase, small subunit superfamily
49 141 Gene3D G3DSA:1.10.1510.20 Propanediol/glycerol dehydratase, small subunit
49 141 InterPro IPR036091 Propanediol/glycerol dehydratase, small subunit superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 1IWP
X-ray 2.10 Å G,M
100.0% 1-141
PDBe RCSB PDBj File
Viewing
PDB 1MMF
X-ray 2.50 Å G,M
100.0% 1-141
PDBe RCSB PDBj File
Loaded
ColabFold KP13_02837
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.971
2 0.906
5 0.663
11 0.496

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 42.62 0.968
2 42.49 0.968
3 15.76 0.761
4 14.89 0.738
5 9.62 0.517