Protein profile

KP13_02836

glycerol dehydratase reactivase

Genome: KpKP13

Gene: AHE42595.1 Structure source: Experimental + ColabFold UniProt Q59474
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Amino acids 607
Annotations 4
Features 21
PDB binders 0
Druggability 0.938

Overview

Basic information about this protein and its source genome.

Accession
KP13_02836
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42595.1
Status
annotated
Amino acids
607
Structure source
Experimental + ColabFold
EC
4.2.1.30
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046405 Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
92.94

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.938
Structure 1NBW
Pocket Pocket 21
P2Rank 0.967
Structure 1NBW
Pocket Pocket 1
ColabFold model
FPocket 0.947 · Pocket 10
P2Rank 0.985 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 161 / 4744 genomes with a hit
Normalized 0.034

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0046405 Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
92 256 Pfam PF18427 DD-reactivating factor swiveling domain
92 256 InterPro IPR040916 DD-reactivating factor swiveling domain
1 607 PIRSF PIRSF011502 DdrA_PduG
1 607 InterPro IPR009191 Diol dehydratase-reactivating factor large subunit
278 602 Pfam PF08841 Diol dehydratase reactivase ATPase-like domain
278 602 InterPro IPR030994 Diol dehydratase reactivase ATPase-like domain
92 256 SUPERFAMILY SSF82317 Swiveling domain of dehydratase reactivase alpha subunit
92 256 InterPro IPR028975 Diol dehydratase-reactivating factor, alpha subunit, swiveling domain superfamily
411 604 SUPERFAMILY SSF53067 Actin-like ATPase domain
411 604 InterPro IPR043129 ATPase, nucleotide binding domain
96 249 Gene3D G3DSA:3.50.30.70 Swiveling domain of dehydratase reactivase alpha subunit
96 249 InterPro IPR028975 Diol dehydratase-reactivating factor, alpha subunit, swiveling domain superfamily
3 602 Gene3D G3DSA:3.30.420.40 -
76 372 Gene3D G3DSA:3.90.470.30 -
407 583 Gene3D G3DSA:3.30.420.40 -
3 603 NCBIfam TIGR04491 diol dehydratase reactivase subunit alpha
3 603 InterPro IPR009191 Diol dehydratase-reactivating factor large subunit
250 405 SUPERFAMILY SSF53067 Actin-like ATPase domain
250 405 InterPro IPR043129 ATPase, nucleotide binding domain
468 512 Gene3D G3DSA:2.40.50.140 -
468 512 InterPro IPR012340 Nucleic acid-binding, OB-fold

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 1NBW
X-ray 2.40 Å A,C
100.0% 1-607
PDBe RCSB PDBj File
Viewing
ColabFold KP13_02836
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
80 0.853
73 0.411
59 0.281

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 41.76 0.967
2 34.33 0.95
3 14.0 0.707
4 6.31 0.317
5 5.08 0.232