Protein profile

KP13_02834

hypothetical protein

Genome: KpKP13

Gene: AHE42597.1 Structure source: Experimental + ColabFold UniProt A6TE95
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Amino acids 107
Annotations 2
Features 14
PDB binders 0
Druggability 0.001

Overview

Basic information about this protein and its source genome.

Accession
KP13_02834
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42597.1
Status
annotated
Amino acids
107
Structure source
Experimental + ColabFold
GO
GO:0009268 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. GO:0051082 Binding to an unfolded protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
81.34

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.001
Structure 4XVV
Pocket Pocket 2
P2Rank
Structure 4XVV
Pocket No pockets
ColabFold model
FPocket 0.664 · Pocket 3
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 15 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0009268 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
  • GO:0051082 Binding to an unfolded protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
1 11 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 31 Phobius SIGNAL_PEPTIDE Signal peptide region
13 32 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 31 SignalP_EUK SignalP-noTM SignalP-noTM
31 107 Gene3D G3DSA:1.10.890.10 -
31 107 InterPro IPR038303 HNS-dependent expression A/B superfamily
15 99 Pfam PF06411 HdeA/HdeB family
15 99 InterPro IPR010486 HNS-dependent expression A/B
24 31 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
32 107 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 31 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
8 106 Hamap MF_00947 Acid stress chaperone HdeB [hdeB].
8 106 InterPro IPR028623 HNS-dependent expression B
12 23 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4XVV
X-ray 20.00 Å - —
PDBe RCSB PDBj File
Viewing
ColabFold KP13_02834
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.007
3 0.001
2 0.0
5 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 0.89 0.004