Overview
Basic information about this protein and its source genome.
- Accession
- KP13_02827
- Gene
- mug AHE42604.1
- Status
- annotated
- Amino acids
- 168
- Structure source
- AlphaFold + ColabFold
Target profile
Computed evidence for target prioritization.
- Human off-target
- hit
- Human identity (%)
- 47.5
- Human E-value
- 6.66e-07
- Gut microbiome off-target
- hit
- Essential (DEG)
- N
- DEG identity (%)
- 0.0
- Localization
- Unknown
- ColabFold pLDDT
- 96.06
Selected Druggability evidence
AlphaFold / UniProt modelSelected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
Enzyme Commission (EC)
1Gene Ontology (GO)
6- GO:0006285 The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired.
- GO:0000700 Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.
- GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
- GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
- GO:0008263 Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site.
- GO:0004844 Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine.
Sequence Features
Domain/signature hits from InterPro and related databases.
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 3 | 159 | SMART | SM00986 | UDG_2 |
| 3 | 159 | InterPro | IPR005122 | Uracil-DNA glycosylase-like |
| 3 | 159 | SMART | SM00987 | UDG_2_a |
| 2 | 162 | PANTHER | PTHR12159 | G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE |
| 2 | 162 | InterPro | IPR015637 | Uracil DNA glycosylase family 2 |
| 1 | 168 | Hamap | MF_01956 | G/U mismatch-specific DNA glycosylase [mug]. |
| 1 | 168 | InterPro | IPR023502 | G/U mismatch-specific DNA glycosylase MUG, bacterial |
| 1 | 168 | Gene3D | G3DSA:3.40.470.10 | - |
| 1 | 168 | InterPro | IPR036895 | Uracil-DNA glycosylase-like domain superfamily |
| 6 | 159 | Pfam | PF03167 | Uracil DNA glycosylase superfamily |
| 6 | 159 | InterPro | IPR005122 | Uracil-DNA glycosylase-like |
| 2 | 159 | CDD | cd10028 | UDG-F2_TDG_MUG |
| 2 | 159 | InterPro | IPR015637 | Uracil DNA glycosylase family 2 |
| 2 | 161 | SUPERFAMILY | SSF52141 | Uracil-DNA glycosylase-like |
| 2 | 161 | InterPro | IPR036895 | Uracil-DNA glycosylase-like domain superfamily |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
Structural evidence
0 + 2Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
AF_A0A0H3GTH2
|
AlphaFold | — | — | full sequence | — | Viewing |
|
ColabFold
KP13_02827
|
ColabFold | — | — | full sequence | — | Loaded |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 1 | 0.868 |
Pockets (P2RANK)
Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).
| P2RANK | Sticks | Spheres | Surfaces | Score | Probability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|---|
| 1 | 11.09 | 0.595 |
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 9 | 0.836 |
Pockets (P2RANK)
Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).
| P2RANK | Sticks | Spheres | Surfaces | Score | Probability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|---|
| 1 | 10.98 | 0.589 |
Ligand evidence
Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.
Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.
No PDB structure with a co-crystallized ligand found for this exact protein.
Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.
Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL bioactivity data found for this exact protein.
Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL hits found through similar proteins.
Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).
| Ligand | Tanimoto | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|
| ZINC62714228 | 0.613 | 202.2 Da LogP -0.71 TPSA 85.9 | ✓ Ro5 | ✓ Clean |
O=c1[nH]cc(CSCCO)c(=O)[nH]1
|
| ZINC1682039 | 0.594 | 229.2 Da LogP -2.15 TPSA 109.4 | ✓ Ro5 | ✓ Clean |
O=c1[nH]cc(CN(CCO)CCO)c(=O)[nH]1
|
| ZINC1615551 | 0.586 | 314.3 Da LogP -2.45 TPSA 165.6 | ✓ Ro5 | ✓ Clean |
O=c1[nH]cc(CS(=O)(=O)Cc2c[nH]c(=O)[nH]c2=O)c(=O…
|
| ZINC95095499 | 0.567 | 279.3 Da LogP -1.93 TPSA 134.7 | ✓ Ro5 | ✓ Clean |
CN(Cc1c[nH]c(=O)[nH]c1=O)Cc1c[nH]c(=O)[nH]c1=O
|
| ZINC967457 | 0.567 | 237.0 Da LogP -0.04 TPSA 71.8 | ✓ Ro5 | ✓ Clean |
Nc1nc(=O)[nH]cc1I
|
| ZINC3682955 | 0.545 | 218.2 Da LogP 0.36 TPSA 85.9 | ✓ Ro5 | ✓ Clean |
O=c1[nH]cc(Cc2ccc(O)cc2)c(=O)[nH]1
|
| ZINC1727445 | 0.537 | 256.2 Da LogP -2.08 TPSA 158.4 | ✓ Ro5 | ✓ Clean |
C[C@H](O)[C@H](NC(=O)c1c[nH]c(=O)nc1N)C(=O)O
|
| ZINC1727446 | 0.537 | 256.2 Da LogP -2.08 TPSA 158.4 | ✓ Ro5 | ✓ Clean |
C[C@@H](O)[C@H](NC(=O)c1c[nH]c(=O)nc1N)C(=O)O
|
| ZINC1727447 | 0.537 | 256.2 Da LogP -2.08 TPSA 158.4 | ✓ Ro5 | ✓ Clean |
C[C@H](O)[C@@H](NC(=O)c1c[nH]c(=O)nc1N)C(=O)O
|
| ZINC1727448 | 0.537 | 256.2 Da LogP -2.08 TPSA 158.4 | ✓ Ro5 | ✓ Clean |
C[C@@H](O)[C@@H](NC(=O)c1c[nH]c(=O)nc1N)C(=O)O
|
| ZINC1670654 | 0.531 | 202.2 Da LogP 0.65 TPSA 65.7 | ✓ Ro5 | ✓ Clean |
O=c1[nH]cc(Cc2ccccc2)c(=O)[nH]1
|
| ZINC1734749 | 0.515 | 216.2 Da LogP 0.85 TPSA 65.7 | ✓ Ro5 | ✓ Clean |
O=c1[nH]cc(CCc2ccccc2)c(=O)[nH]1
|
| ZINC2546072 | 0.514 | 217.2 Da LogP 0.53 TPSA 95.9 | ✓ Ro5 | ✓ Clean |
O=C(O)c1c[nH]c(=O)nc1-c1ccncc1
|
| ZINC181793 | 0.500 | 209.2 Da LogP 0.05 TPSA 69.0 | ✓ Ro5 | ✓ Clean |
O=c1[nH]cc(CN2CCCCC2)c(=O)[nH]1
|
PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.