Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: KP13_31483
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: rpsU AHE42607.1
Status: annotated
Amino acids: 77
Structure source: AlphaFold + ColabFold

GO

GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:1990904 A macromolecular complex that contains both RNA and protein molecules.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 100.0
DEG E-value: 2.4e-45
Localization: Cytoplasmic
ColabFold pLDDT: 84.39

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.801

Structure A0A0H3GXT4

Pocket Pocket 5

P2Rank

Structure A0A0H3GXT4

Pocket No pockets

ColabFold model

FPocket 0.139 · Pocket 4

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 993 / 4744 genomes with a hit

Normalized 0.209

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome.
GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
GO:1990904 A macromolecular complex that contains both RNA and protein molecules.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records

Show feature table

Start	End	DB	Term	Name
53	77	MobiDBLite	mobidb-lite	consensus disorder prediction
22	60	FunFam	G3DSA:1.20.5.1150:FF:000001	30S ribosomal protein S21
31	41	PRINTS	PR00976	Ribosomal protein S21 family signature
31	41	InterPro	IPR001911	Ribosomal protein S21
11	19	PRINTS	PR00976	Ribosomal protein S21 family signature
11	19	InterPro	IPR001911	Ribosomal protein S21
19	28	PRINTS	PR00976	Ribosomal protein S21 family signature
19	28	InterPro	IPR001911	Ribosomal protein S21
43	53	PRINTS	PR00976	Ribosomal protein S21 family signature
43	53	InterPro	IPR001911	Ribosomal protein S21
55	69	MobiDBLite	mobidb-lite	consensus disorder prediction
10	65	PANTHER	PTHR21109	MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S21
10	65	InterPro	IPR001911	Ribosomal protein S21
8	65	NCBIfam	TIGR00030	30S ribosomal protein S21
8	65	InterPro	IPR001911	Ribosomal protein S21
10	62	Pfam	PF01165	Ribosomal protein S21
10	62	InterPro	IPR001911	Ribosomal protein S21
19	31	ProSitePatterns	PS01181	Ribosomal protein S21 signature.
19	31	InterPro	IPR018278	Ribosomal protein S21, conserved site
22	60	Gene3D	G3DSA:1.20.5.1150	Ribosomal protein S8
22	60	InterPro	IPR038380	Ribosomal protein S21 superfamily
7	63	Hamap	MF_00358	30S ribosomal protein S21 [rpsU].
7	63	InterPro	IPR001911	Ribosomal protein S21

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GXT4	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_31483	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
5				0.801

KP13_31483