Protein profile

KP13_02819

Urease accessory protein ureF

Genome: KpKP13

Gene: ureF AHE42611.1 Structure source: Experimental + ColabFold UniProt A6TE44
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Amino acids 224
Annotations 2
Features 9
PDB binders 0
Druggability 0.543

Overview

Basic information about this protein and its source genome.

Accession
KP13_02819
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ureF AHE42611.1
Status
annotated
Amino acids
224
Structure source
Experimental + ColabFold
GO
GO:0006807 OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. GO:0016151 Binding to a nickel (Ni) cation.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
96.22

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.543
Structure 6JC4
Pocket Pocket 5
P2Rank 0.312
Structure 6JC4
Pocket Pocket 1
ColabFold model
FPocket 0.334 · Pocket 10
P2Rank 0.897 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 37 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0006807 OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.
  • GO:0016151 Binding to a nickel (Ni) cation.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
6 224 Hamap MF_01385 Urease accessory protein UreF [ureF].
6 224 InterPro IPR002639 Urease accessory protein UreF
2 203 Gene3D G3DSA:1.10.4190.10 Urease accessory protein UreF
2 203 InterPro IPR038277 UreF domain superfamily
40 181 Pfam PF01730 UreF
40 181 InterPro IPR002639 Urease accessory protein UreF
1 224 PANTHER PTHR33620 UREASE ACCESSORY PROTEIN F
3 224 PIRSF PIRSF009467 Urease_acces_UreF
3 224 InterPro IPR002639 Urease accessory protein UreF

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 6JC4
X-ray 20.00 Å - —
PDBe RCSB PDBj File
Viewing
ColabFold KP13_02819
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
9 0.616
3 0.363
1 0.295

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.3 0.316
2 5.79 0.282
3 5.79 0.282
4 3.93 0.155
5 1.87 0.037