Protein profile

KP13_02818

Urease accessory protein ureE

Genome: KpKP13

Gene: AHE42612.1 ureE Structure source: AlphaFold + ColabFold UniProt A0A0H3GXT1
Export view
Amino acids 158
Annotations 6
Features 18
PDB binders 0
Druggability 0.66

Overview

Basic information about this protein and its source genome.

Accession
KP13_02818
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42612.1 ureE
Status
annotated
Amino acids
158
Structure source
AlphaFold + ColabFold
GO
GO:0019627 The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2. GO:0016151 Binding to a nickel (Ni) cation. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006457 The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. GO:0065003 The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. GO:0051082 Binding to an unfolded protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
90.1

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.66
Structure A0A0H3GXT1
Pocket Pocket 1
P2Rank
Structure A0A0H3GXT1
Pocket No pockets
ColabFold model
FPocket 0.592 · Pocket 4
P2Rank 0.005 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 51 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0019627 The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2.
  • GO:0016151 Binding to a nickel (Ni) cation.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0006457 The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
  • GO:0065003 The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
  • GO:0051082 Binding to an unfolded protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
2 139 Hamap MF_00822 Urease accessory protein UreE [ureE].
2 139 InterPro IPR012406 Urease accessory protein UreE
72 143 Gene3D G3DSA:3.30.70.790 -
1 64 SMART SM00988 UreE_n_2_a
1 64 InterPro IPR004029 UreE urease accessory, N-terminal
3 156 PIRSF PIRSF036402 Ureas_acces_UreE
3 156 InterPro IPR012406 Urease accessory protein UreE
138 158 MobiDBLite mobidb-lite consensus disorder prediction
73 158 Pfam PF05194 UreE urease accessory protein, C-terminal domain
73 158 InterPro IPR007864 Urease accessory protein UreE, C-terminal domain
71 138 SUPERFAMILY SSF69737 Urease metallochaperone UreE, C-terminal domain
8 132 CDD cd00571 UreE
8 132 InterPro IPR012406 Urease accessory protein UreE
1 71 Gene3D G3DSA:2.60.260.20 -
1 70 SUPERFAMILY SSF69287 Urease metallochaperone UreE, N-terminal domain
1 70 InterPro IPR036118 UreE urease accessory, N-terminal domain superfamily
9 62 Pfam PF02814 UreE urease accessory protein, N-terminal domain
9 62 InterPro IPR004029 UreE urease accessory, N-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GXT1
AlphaFold — — full sequence — Viewing
ColabFold KP13_02818
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.66