Protein profile

KP13_31792

transposase for insertion sequence element IS1328

Genome: KpKP13

Gene: AHE42613.1 Structure source: ColabFold
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Amino acids 293
Annotations 3
Features 9
PDB binders 0
Druggability 0.869

Overview

Basic information about this protein and its source genome.

Accession
KP13_31792
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42613.1
Status
annotated
Amino acids
293
Structure source
ColabFold
GO
GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
93.5

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.869
Structure CB_KP13_31792
Pocket Pocket 5
P2Rank 0.036
Structure CB_KP13_31792
Pocket Pocket 1
ColabFold model
FPocket 0.869 · Pocket 5
P2Rank 0.036 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 19 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element.
  • GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
169 244 Pfam PF02371 Transposase IS116/IS110/IS902 family
169 244 InterPro IPR003346 Transposase IS116/IS110/IS902, C-terminal
7 106 Pfam PF01548 Transposase
7 106 InterPro IPR002525 Transposase IS110-like, N-terminal
2 289 NCBIfam NF033542 IS110 family transposase
2 289 InterPro IPR047650 Transposase IS110-like
8 292 PANTHER PTHR33055 TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1111A
8 292 InterPro IPR047650 Transposase IS110-like
144 164 Coils Coil Coil

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold KP13_31792
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.869
2 0.213