Protein profile

KP13_02813

Urease accessory protein ureD

Genome: KpKP13

Gene: AHE42617.1 ureD Structure source: Experimental + ColabFold UniProt A0A9Q6A135
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Amino acids 270
Annotations 2
Features 6
PDB binders 0
Druggability 0.385

Overview

Basic information about this protein and its source genome.

Accession
KP13_02813
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42617.1 ureD
Status
annotated
Amino acids
270
Structure source
Experimental + ColabFold
GO
GO:0006807 OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. GO:0016151 Binding to a nickel (Ni) cation.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
96.0

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.385
Structure 8HCN
Pocket Pocket 5
P2Rank 0.524
Structure 8HCN
Pocket Pocket 1
ColabFold model
FPocket 0.882 · Pocket 3
P2Rank 0.754 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 35 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0006807 OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.
  • GO:0016151 Binding to a nickel (Ni) cation.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
9 254 Hamap MF_01384 Urease accessory protein UreD [ureD].
9 254 InterPro IPR002669 Urease accessory protein UreD
8 191 PANTHER PTHR33643 UREASE ACCESSORY PROTEIN D
8 191 InterPro IPR002669 Urease accessory protein UreD
50 239 Pfam PF01774 UreD urease accessory protein
50 239 InterPro IPR002669 Urease accessory protein UreD

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 8HCN
X-ray 20.00 Å - —
PDBe RCSB PDBj File
Viewing
ColabFold KP13_02813
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
45 0.924
3 0.821
47 0.8
7 0.672

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 21.0 0.864
2 16.33 0.776
3 14.14 0.713
4 13.01 0.671
5 12.75 0.661