Protein profile

KP13_02807

SH3-like domain-containing protein

Genome: KpKP13

Gene: AHE42623.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYL2
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Amino acids 206
Annotations 1
Features 22
PDB binders 0
Druggability 0.984

Overview

Basic information about this protein and its source genome.

Accession
KP13_02807
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42623.1
Status
annotated
Amino acids
206
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
41.081
DEG E-value
2.5e-37
Localization
Unknown
ColabFold pLDDT
81.87

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.984
Structure A0A0H3GYL2
Pocket Pocket 1
P2Rank
Structure A0A0H3GYL2
Pocket No pockets
ColabFold model
FPocket 0.475 · Pocket 2
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 109 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
127 168 Coils Coil Coil
36 81 Pfam PF08239 Bacterial SH3 domain
36 81 InterPro IPR003646 SH3-like domain, bacterial-type
173 195 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
6 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
196 206 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 205 PIRSF PIRSF006158 UCP006158_SH3
1 205 InterPro IPR016476 SH3 domain protein
26 83 Gene3D G3DSA:2.30.30.40 SH3 Domains
23 89 SMART SM00287 sh3_bac_9
23 89 InterPro IPR003646 SH3-like domain, bacterial-type
1 22 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 22 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
18 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
27 204 NCBIfam TIGR04211 TIGR04211 family SH3 domain-containing protein
27 204 InterPro IPR016476 SH3 domain protein
95 115 Coils Coil Coil
23 89 ProSiteProfiles PS51781 SH3b domain profile.
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
173 195 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
23 172 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYL2
AlphaFold — — full sequence — Viewing
ColabFold KP13_02807
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.984
5 0.738