Amino acids
256
Annotations
5
Features
28
PDB binders
0
Druggability
0.766
Overview
Basic information about this protein and its source genome.
- Accession
- KP13_02800
- Gene
- zupT AHE42631.1
- Status
- annotated
- Amino acids
- 256
- Structure source
- AlphaFold + ColabFold
GO
GO:0030001 The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:0046873 Enables the transfer of metal ions from one side of a membrane to the other.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0005385 Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.
Target profile
Computed evidence for target prioritization.
- Human off-target
- hit
- Human identity (%)
- 39.785
- Human E-value
- 1.53e-08
- Gut microbiome off-target
- hit
- Essential (DEG)
- N
- DEG identity (%)
- 0.0
- Localization
- CytoplasmicMembrane
- ColabFold pLDDT
- 89.57
Selected Druggability evidence
AlphaFold / UniProt modelSelected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
FPocket
0.766
P2Rank
0.207
ColabFold model
Core conservation
Conserved core gene
Gut microbiome
68 / 4744
genomes with a hit
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
5 GO
Gene Ontology (GO)
5- GO:0030001 The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
- GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
- GO:0046873 Enables the transfer of metal ions from one side of a membrane to the other.
- GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
- GO:0005385 Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.
Sequence Features
Domain/signature hits from InterPro and related databases.
28 records
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 197 | 214 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 192 | 196 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 194 | 216 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 140 | 162 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 1 | 5 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 26 | 31 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 136 | 162 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 5 | 25 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 32 | 53 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 108 | 130 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 65 | 87 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 54 | 64 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 169 | 190 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 32 | 50 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 6 | 25 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 87 | 106 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 233 | 255 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 9 | 244 | PANTHER | PTHR11040 | ZINC/IRON TRANSPORTER |
| 163 | 168 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 256 | 256 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 65 | 86 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 103 | 245 | Pfam | PF02535 | ZIP Zinc transporter |
| 103 | 245 | InterPro | IPR003689 | Zinc/iron permease |
| 234 | 255 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 131 | 135 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 107 | 130 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 169 | 191 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 215 | 233 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
Legend
High
Medium
Low
Structural evidence
0 + 2Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
AF_A0A0H3GVR3
|
AlphaFold | — | — | full sequence | — | Viewing |
|
ColabFold
KP13_02800
|
ColabFold | — | — | full sequence | — | Loaded |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 3 | 0.766 | ||||||
| 2 | 0.236 |
Pockets (P2RANK)
Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).
| P2RANK | Sticks | Spheres | Surfaces | Score | Probability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|---|
| 1 | 4.3 | 0.178 | ||||||
| 2 | 4.1 | 0.165 | ||||||
| 3 | 2.38 | 0.063 | ||||||
| 4 | 1.89 | 0.038 | ||||||
| 5 | 1.45 | 0.02 |
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 3 | 0.539 | ||||||
| 2 | 0.231 |
Pockets (P2RANK)
Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).
| P2RANK | Sticks | Spheres | Surfaces | Score | Probability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|---|
| 1 | 3.24 | 0.112 | ||||||
| 2 | 2.27 | 0.057 | ||||||
| 3 | 1.93 | 0.04 | ||||||
| 4 | 1.52 | 0.022 |