Protein profile

KP13_02799

dioxygenase class III protein, subunit B

Genome: KpKP13

Gene: AHE42632.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GXS0
Export view
Amino acids 247
Annotations 8
Features 10
PDB binders 0
Druggability 0.438

Overview

Basic information about this protein and its source genome.

Accession
KP13_02799
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42632.1
Status
annotated
Amino acids
247
Structure source
AlphaFold + ColabFold
EC
1.13.11.29
GO
GO:0008270 Binding to a zinc ion (Zn). GO:0006725 OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. GO:0016701 Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. GO:0008198 Binding to a ferrous iron ion, Fe(II). GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
97.07

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.438
Structure A0A0H3GXS0
Pocket Pocket 2
P2Rank 0.593
Structure A0A0H3GXS0
Pocket Pocket 1
ColabFold model
FPocket 0.213 · Pocket 1
P2Rank 0.985 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 112 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 7 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

7
  • GO:0008270 Binding to a zinc ion (Zn).
  • GO:0006725 OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
  • GO:0016701 Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor.
  • GO:0008198 Binding to a ferrous iron ion, Fe(II).
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0050297 Catalysis of the reaction: L-dopa + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H+.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
14 238 Pfam PF02900 Catalytic LigB subunit of aromatic ring-opening dioxygenase
14 238 InterPro IPR004183 Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B
1 247 PIRSF PIRSF006157 Doxgns_DODA
1 247 InterPro IPR014436 Extradiol aromatic ring-opening dioxygenase, DODA-type
1 244 CDD cd07363 45_DOPA_Dioxygenase
1 244 InterPro IPR014436 Extradiol aromatic ring-opening dioxygenase, DODA-type
1 245 SUPERFAMILY SSF53213 LigB-like
9 243 PANTHER PTHR30096 UNCHARACTERIZED
1 246 FunFam G3DSA:3.40.830.10:FF:000003 4,5-DOPA dioxygenase extradiol
1 246 Gene3D G3DSA:3.40.830.10 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GXS0
AlphaFold — — full sequence — Viewing
ColabFold KP13_02799
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.438

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.73 0.467
2 1.71 0.03
3 0.88 0.004
4 0.73 0.002