Protein profile

KP13_02789

Modulator of drug activity B

Genome: KpKP13

Gene: AHE42642.1 mdaB Structure source: AlphaFold + ColabFold UniProt A0A0H3GXR4
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Amino acids 193
Annotations 3
Features 8
PDB binders 0
Druggability 0.586

Overview

Basic information about this protein and its source genome.

Accession
KP13_02789
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42642.1 mdaB
Status
annotated
Amino acids
193
Structure source
AlphaFold + ColabFold
EC
1.6.5.10
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008753 Catalysis of the reaction: NADPH + H+ + a quinone = NADP+ + a quinol.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
97.25

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.586
Structure A0A0H3GXR4
Pocket Pocket 5
P2Rank 0.588
Structure A0A0H3GXR4
Pocket Pocket 1
ColabFold model
FPocket 0.331 · Pocket 2
P2Rank 0.625 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 184 / 4744 genomes with a hit
Normalized 0.039

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0008753 Catalysis of the reaction: NADPH + H+ + a quinone = NADP+ + a quinol.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
1 193 FunFam G3DSA:3.40.50.360:FF:000007 Drug activity modulator B
1 193 Gene3D G3DSA:3.40.50.360 -
1 193 InterPro IPR029039 Flavoprotein-like superfamily
3 188 Pfam PF02525 Flavodoxin-like fold
3 188 InterPro IPR003680 Flavodoxin-like fold
1 192 SUPERFAMILY SSF52218 Flavoproteins
1 192 InterPro IPR029039 Flavoprotein-like superfamily
2 192 PANTHER PTHR46305 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GXR4
AlphaFold — — full sequence — Viewing
ColabFold KP13_02789
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.586
3 0.011
4 0.01
6 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.99 0.588
2 3.52 0.103
3 1.16 0.008