Protein profile

KP13_02785

AraC family transcriptional regulator

Genome: KpKP13

Gene: AHE42646.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GVP6
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Amino acids 289
Annotations 3
Features 27
PDB binders 0
Druggability 0.876

Overview

Basic information about this protein and its source genome.

Accession
KP13_02785
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42646.1
Status
annotated
Amino acids
289
Structure source
AlphaFold + ColabFold
GO
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
92.66

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.876
Structure A0A0H3GVP6
Pocket Pocket 22
P2Rank 0.989
Structure A0A0H3GVP6
Pocket Pocket 1
ColabFold model
FPocket 0.894 · Pocket 4
P2Rank 0.987 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 21 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

27 records
Show feature table
Start End DB Term Name
81 96 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
81 96 InterPro IPR020449 Transcription regulator HTH, AraC- type
96 112 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
96 112 InterPro IPR020449 Transcription regulator HTH, AraC- type
28 112 SMART SM00342 aracneu4
28 112 InterPro IPR018060 DNA binding HTH domain, AraC-type
34 114 Pfam PF12833 Helix-turn-helix domain
34 114 InterPro IPR018060 DNA binding HTH domain, AraC-type
65 108 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature.
65 108 InterPro IPR018062 HTH domain AraC-type, conserved site
15 114 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
15 114 InterPro IPR018060 DNA binding HTH domain, AraC-type
12 62 SUPERFAMILY SSF46689 Homeodomain-like
12 62 InterPro IPR009057 Homeobox-like domain superfamily
135 289 SMART SM00871 AraC_E_bind_2
135 289 InterPro IPR010499 Bacterial transcription activator, effector binding
70 127 Gene3D G3DSA:1.10.10.60 -
135 288 Pfam PF06445 GyrI-like small molecule binding domain
135 288 InterPro IPR029442 GyrI-like small molecule binding domain
135 289 Gene3D G3DSA:3.20.80.10 Regulatory factor, effector binding domain
135 289 InterPro IPR011256 Regulatory factor, effector binding domain superfamily
135 288 SUPERFAMILY SSF55136 Probable bacterial effector-binding domain
135 288 InterPro IPR011256 Regulatory factor, effector binding domain superfamily
10 69 Gene3D G3DSA:1.10.10.60 -
4 288 PANTHER PTHR40055 TRANSCRIPTIONAL REGULATOR YGIV-RELATED
64 120 SUPERFAMILY SSF46689 Homeodomain-like
64 120 InterPro IPR009057 Homeobox-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVP6
AlphaFold — — full sequence — Viewing
ColabFold KP13_02785
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
22 0.876

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 55.79 0.984
2 7.27 0.379
3 3.88 0.152