Protein profile

KP13_02781

elongator protein 3/MiaB/NifB domain-containing protein

Genome: KpKP13

Gene: AHE42650.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H356
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Amino acids 757
Annotations 3
Features 27
PDB binders 0
Druggability 0.546

Overview

Basic information about this protein and its source genome.

Accession
KP13_02781
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42650.1
Status
annotated
Amino acids
757
Structure source
AlphaFold + ColabFold
GO
GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
86.11

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.546
Structure A0A0H3H356
Pocket Pocket 5
P2Rank 0.961
Structure A0A0H3H356
Pocket Pocket 1
ColabFold model
FPocket 0.754 · Pocket 7
P2Rank 0.959 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 127 / 4744 genomes with a hit
Normalized 0.027

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
  • GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.

Sequence Features

Domain/signature hits from InterPro and related databases.

27 records
Show feature table
Start End DB Term Name
45 730 SFLD SFLDG01069 UPF0313
45 730 InterPro IPR022946 Uncharacterised protein family UPF0313
410 430 ProSitePatterns PS01278 Methylthiotransferase radical SAM domain signature.
410 430 InterPro IPR020612 Methylthiotransferase, conserved site
59 409 Pfam PF08497 Radical SAM N-terminal
59 409 InterPro IPR013704 UPF0313, N-terminal
405 648 Gene3D G3DSA:3.80.30.20 tm_1862 like domain
405 648 InterPro IPR023404 Radical SAM, alpha/beta horseshoe
76 634 SFLD SFLDG01082 B12-binding domain containing
43 722 PANTHER PTHR32331 UPF0313 PROTEIN YGIQ
43 722 InterPro IPR022946 Uncharacterised protein family UPF0313
624 743 Pfam PF11842 Domain of unknown function (DUF3362)
624 743 InterPro IPR024560 UPF0313, C-terminal
401 676 SUPERFAMILY SSF102114 Radical SAM enzymes
59 676 Hamap MF_01251 UPF0313 protein YgiQ [ygiQ].
59 676 InterPro IPR022946 Uncharacterised protein family UPF0313
59 674 NCBIfam TIGR03904 YgiQ family radical SAM protein
59 674 InterPro IPR022946 Uncharacterised protein family UPF0313
45 730 SFLD SFLDS00029 Radical SAM
45 730 InterPro IPR007197 Radical SAM
402 680 ProSiteProfiles PS51918 Radical SAM core domain profile.
402 680 InterPro IPR007197 Radical SAM
406 656 SMART SM00729 MiaB
406 656 InterPro IPR006638 Elp3/MiaA/NifB-like, radical SAM core domain
718 757 MobiDBLite mobidb-lite consensus disorder prediction
410 615 Pfam PF04055 Radical SAM superfamily
410 615 InterPro IPR007197 Radical SAM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H356
AlphaFold — — full sequence — Viewing
ColabFold KP13_02781
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.546
31 0.017
51 0.001
12 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 46.61 0.961
2 10.42 0.482
3 7.17 0.312
4 5.53 0.218
5 3.11 0.084