Protein profile

KP13_02780

GCN5-related N-acetyltransferase (GNAT) domain-containing protein

Genome: KpKP13

Gene: AHE42651.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GVP1
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Amino acids 176
Annotations 1
Features 8
PDB binders 0
Druggability 0.885

Overview

Basic information about this protein and its source genome.

Accession
KP13_02780
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42651.1
Status
annotated
Amino acids
176
Structure source
AlphaFold + ColabFold
GO
GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
96.37

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.885
Structure A0A0H3GVP1
Pocket Pocket 1
P2Rank 0.919
Structure A0A0H3GVP1
Pocket Pocket 1
ColabFold model
FPocket 0.627 · Pocket 2
P2Rank 0.922 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 6 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
7 160 Gene3D G3DSA:3.40.630.30 -
62 148 Pfam PF00583 Acetyltransferase (GNAT) family
62 148 InterPro IPR000182 GNAT domain
69 135 CDD cd04301 NAT_SF
13 176 ProSiteProfiles PS51186 Gcn5-related N-acetyltransferase (GNAT) domain profile.
13 176 InterPro IPR000182 GNAT domain
12 155 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
12 155 InterPro IPR016181 Acyl-CoA N-acyltransferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVP1
AlphaFold — — full sequence — Viewing
ColabFold KP13_02780
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.885

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 24.22 0.897
2 1.58 0.025