Protein profile

KP13_02769

hypothetical protein

Genome: KpKP13

Gene: AHE42662.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GXQ2
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Amino acids 164
Annotations 1
Features 21
PDB binders 0
Druggability 0.728

Overview

Basic information about this protein and its source genome.

Accession
KP13_02769
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42662.1
Status
annotated
Amino acids
164
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
89.634
DEG E-value
6.61e-101
Localization
CytoplasmicMembrane
ColabFold pLDDT
88.21

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.728
Structure A0A0H3GXQ2
Pocket Pocket 2
P2Rank 0.009
Structure A0A0H3GXQ2
Pocket Pocket 1
ColabFold model
FPocket 0.783 · Pocket 3
P2Rank 0.009 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 108 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
138 156 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
12 34 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
35 53 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
109 126 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
127 137 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
76 108 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
54 75 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 162 NCBIfam TIGR00645 TIGR00645 family protein
1 162 InterPro IPR020761 Uncharacterised protein family UPF0114, bacteria
2 162 PANTHER PTHR38596 UPF0114 PROTEIN YQHA
2 162 InterPro IPR020761 Uncharacterised protein family UPF0114, bacteria
55 77 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 164 Hamap MF_00143 UPF0114 protein YqhA [yqhA].
1 164 InterPro IPR020761 Uncharacterised protein family UPF0114, bacteria
9 125 Pfam PF03350 Uncharacterized protein family, UPF0114
9 125 InterPro IPR005134 Uncharacterised protein family UPF0114
136 155 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
157 164 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
109 126 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GXQ2
AlphaFold — — full sequence — Viewing
ColabFold KP13_02769
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.728
1 0.424
6 0.281