Protein profile

KP13_02768

hypothetical protein

Genome: KpKP13

Gene: AHE42663.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYH5
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Amino acids 296
Annotations 1
Features 7
PDB binders 0
Druggability 0.441

Overview

Basic information about this protein and its source genome.

Accession
KP13_02768
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42663.1
Status
annotated
Amino acids
296
Structure source
AlphaFold + ColabFold
GO
GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
26.577
Human E-value
8.92e-10
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
97.21

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.441
Structure A0A0H3GYH5
Pocket Pocket 6
P2Rank 0.588
Structure A0A0H3GYH5
Pocket Pocket 1
ColabFold model
FPocket 0.59 · Pocket 1
P2Rank 0.559 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 45 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
71 295 SUPERFAMILY SSF53474 alpha/beta-Hydrolases
71 295 InterPro IPR029058 Alpha/Beta hydrolase fold
80 295 PANTHER PTHR46623 CARBOXYMETHYLENEBUTENOLIDASE-RELATED
59 295 Gene3D G3DSA:3.40.50.1820 alpha/beta hydrolase
59 295 InterPro IPR029058 Alpha/Beta hydrolase fold
85 294 Pfam PF01738 Dienelactone hydrolase family
85 294 InterPro IPR002925 Dienelactone hydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYH5
AlphaFold — — full sequence — Viewing
ColabFold KP13_02768
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.441

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.83 0.473
2 5.8 0.283
3 1.15 0.009