Protein profile

KP13_02765

Thioredoxin-like fold domain-containing protein

Genome: KpKP13

Gene: AHE42666.1 Structure source: AlphaFold + ColabFold UniProt A0A377V975
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Amino acids 164
Annotations 0
Features 4
PDB binders 0
Druggability 0.23

Overview

Basic information about this protein and its source genome.

Accession
KP13_02765
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42666.1
Status
annotated
Amino acids
164
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
98.09

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.23
Structure A0A377V975
Pocket Pocket 8
P2Rank 0.38
Structure A0A377V975
Pocket Pocket 1
ColabFold model
FPocket 0.156 · Pocket 8
P2Rank 0.435 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 27 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

4 records
Show feature table
Start End DB Term Name
2 151 SUPERFAMILY SSF52833 Thioredoxin-like
2 151 InterPro IPR036249 Thioredoxin-like superfamily
1 162 Gene3D G3DSA:3.40.30.10 Glutaredoxin
1 160 PANTHER PTHR33875 OS09G0542200 PROTEIN

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A377V975
AlphaFold — — full sequence — Viewing
ColabFold KP13_02765
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.23

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.06 0.366
2 2.91 0.093
3 2.05 0.045
4 1.76 0.032