Protein profile

KP13_02750

putative transposase

Genome: KpKP13

Gene: AHE42680.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTB4

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Amino acids 50

Annotations 3

Features 4

PDB binders 0

Druggability 0.164

Overview

Basic information about this protein and its source genome.

Accession: KP13_02750
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: AHE42680.1
Status: annotated
Amino acids: 50
Structure source: AlphaFold + ColabFold

GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 55.263
DEG E-value: 1.39e-07
Localization: Unknown
ColabFold pLDDT: 79.64

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.164

Structure A0A0H3GTB4

Pocket Pocket 5

P2Rank 0.002

Structure A0A0H3GTB4

Pocket Pocket 1

ColabFold model

FPocket 0.179 · Pocket 3

Core conservation Accessory gene

Roary accessory

CoreCruncher accessory

Gut microbiome 11 / 4744 genomes with a hit

Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element.
GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

4 records

Show feature table

Start	End	DB	Term	Name
2	37	Pfam	PF01527	Transposase
2	37	InterPro	IPR002514	Transposase IS3/IS911family
1	38	SUPERFAMILY	SSF46689	Homeodomain-like
1	38	InterPro	IPR009057	Homeobox-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GTB4	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_02750	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Sticks	Spheres	Surfaces	Score	Probability	Labels	Zoom	Positions
1				0.62	0.0