Protein profile

KP13_02745

putative Fe(2+)-trafficking protein

Genome: KpKP13

Gene: AHE42687.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GXJ6
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Amino acids 91
Annotations 3
Features 16
PDB binders 0
Druggability 0.836

Overview

Basic information about this protein and its source genome.

Accession
KP13_02745
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42687.1
Status
annotated
Amino acids
91
Structure source
AlphaFold + ColabFold
GO
GO:0005506 Binding to an iron (Fe) ion. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0034599 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
83.333
DEG E-value
2.77e-54
Localization
Unknown
ColabFold pLDDT
81.31

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.836
Structure A0A0H3GXJ6
Pocket Pocket 1
P2Rank 0.042
Structure A0A0H3GXJ6
Pocket Pocket 1
ColabFold model
FPocket 0.544 · Pocket 3
P2Rank 0.024 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 152 / 4744 genomes with a hit
Normalized 0.032

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005506 Binding to an iron (Fe) ion.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0034599 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
1 90 SUPERFAMILY SSF111148 YggX-like
1 90 InterPro IPR036766 Fe(II) trafficking protein YggX superfamily
12 16 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
17 91 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 91 FunFam G3DSA:1.10.3880.10:FF:000001 Probable Fe(2+)-trafficking protein
1 88 Hamap MF_00686 Probable Fe(2+)-trafficking protein [yggX].
1 88 InterPro IPR007457 Fe(II) trafficking protein YggX
1 90 PANTHER PTHR36965 FE(2+)-TRAFFICKING PROTEIN-RELATED
1 90 InterPro IPR007457 Fe(II) trafficking protein YggX
1 90 PIRSF PIRSF029827 Fe_traffic_YggX
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 91 Gene3D G3DSA:1.10.3880.10 Fe(II) trafficking protein YggX
1 91 InterPro IPR036766 Fe(II) trafficking protein YggX superfamily
1 88 Pfam PF04362 Bacterial Fe(2+) trafficking
1 16 Phobius SIGNAL_PEPTIDE Signal peptide region
4 11 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GXJ6
AlphaFold — — full sequence — Viewing
ColabFold KP13_02745
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.836

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.52 0.022