Protein profile

KP13_02733

putative Holliday junction resolvase

Genome: KpKP13

Gene: AHE42699.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H2U8
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Amino acids 138
Annotations 2
Features 17
PDB binders 0
Druggability 0.351

Overview

Basic information about this protein and its source genome.

Accession
KP13_02733
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42699.1
Status
annotated
Amino acids
138
Structure source
AlphaFold + ColabFold
GO
GO:0006364 Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. GO:0006139 Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
84.783
DEG E-value
3.4900000000000004e-88
Localization
Cytoplasmic
ColabFold pLDDT
84.51

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.351
Structure A0A0H3H2U8
Pocket Pocket 7
P2Rank 0.031
Structure A0A0H3H2U8
Pocket Pocket 1
ColabFold model
FPocket 0.068 · Pocket 8
P2Rank 0.041 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 157 / 4744 genomes with a hit
Normalized 0.033

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0006364 Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
  • GO:0006139 Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
3 103 SMART SM00732 rnase_8s
3 103 InterPro IPR006641 YqgF/RNase H-like domain
4 135 Pfam PF03652 Holliday junction resolvase
4 135 InterPro IPR005227 Putative pre-16S rRNA nuclease
6 135 NCBIfam TIGR00250 Holliday junction resolvase RuvX
6 135 InterPro IPR005227 Putative pre-16S rRNA nuclease
5 136 CDD cd16964 YqgF
5 136 InterPro IPR005227 Putative pre-16S rRNA nuclease
1 138 FunFam G3DSA:3.30.420.140:FF:000002 Putative pre-16S rRNA nuclease
1 138 Gene3D G3DSA:3.30.420.140 -
1 138 InterPro IPR037027 YqgF/RNase H-like domain superfamily
3 138 Hamap MF_00651 Putative pre-16S rRNA nuclease [yqgF].
3 138 InterPro IPR005227 Putative pre-16S rRNA nuclease
3 136 SUPERFAMILY SSF53098 Ribonuclease H-like
3 136 InterPro IPR012337 Ribonuclease H-like superfamily
3 136 PANTHER PTHR33317 POLYNUCLEOTIDYL TRANSFERASE, RIBONUCLEASE H-LIKE SUPERFAMILY PROTEIN
3 136 InterPro IPR005227 Putative pre-16S rRNA nuclease

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H2U8
AlphaFold — — full sequence — Viewing
ColabFold KP13_02733
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.351
1 0.233