Protein profile

KP13_02732

hypothetical protein

Genome: KpKP13

Gene: AHE42700.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GVD4
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Amino acids 187
Annotations 1
Features 9
PDB binders 0
Druggability 0.485

Overview

Basic information about this protein and its source genome.

Accession
KP13_02732
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42700.1
Status
annotated
Amino acids
187
Structure source
AlphaFold + ColabFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
88.77
DEG E-value
7.59e-126
Localization
CytoplasmicMembrane
ColabFold pLDDT
91.96

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.485
Structure A0A0H3GVD4
Pocket Pocket 2
P2Rank 0.163
Structure A0A0H3GVD4
Pocket Pocket 1
ColabFold model
FPocket 0.586 · Pocket 3
P2Rank 0.124 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 117 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
3 168 PANTHER PTHR30327 UNCHARACTERIZED PROTEIN YQGE
3 168 InterPro IPR003774 Protein of unknown function UPF0301
1 187 SUPERFAMILY SSF143456 VC0467-like
6 175 Gene3D G3DSA:3.40.1740.10 -
1 187 Hamap MF_00758 UPF0301 protein YqgE [yqgE].
1 187 InterPro IPR003774 Protein of unknown function UPF0301
41 130 Gene3D G3DSA:3.30.70.1300 -
12 174 Pfam PF02622 Uncharacterized ACR, COG1678
12 174 InterPro IPR003774 Protein of unknown function UPF0301

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVD4
AlphaFold — — full sequence — Viewing
ColabFold KP13_02732
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.485
1 0.372

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.39 0.121
2 1.44 0.019