Protein profile

KP13_02729

Endonuclease-1

Genome: KpKP13

Gene: AHE42703.1 endA Structure source: AlphaFold + ColabFold UniProt A0A0H3GT48
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Amino acids 232
Annotations 3
Features 13
PDB binders 0
Druggability 0.82

Overview

Basic information about this protein and its source genome.

Accession
KP13_02729
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42703.1 endA
Status
annotated
Amino acids
232
Structure source
AlphaFold + ColabFold
GO
GO:0004518 Catalysis of the cleavage of ester linkages within nucleic acids. GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Periplasmic
ColabFold pLDDT
93.61

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.82
Structure A0A0H3GT48
Pocket Pocket 1
P2Rank 0.156
Structure A0A0H3GT48
Pocket Pocket 1
ColabFold model
FPocket 0.721 · Pocket 2
P2Rank 0.097 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 142 / 4744 genomes with a hit
Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0004518 Catalysis of the cleavage of ester linkages within nucleic acids.
  • GO:0004519 Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 30 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
3 14 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
20 232 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 19 Phobius SIGNAL_PEPTIDE Signal peptide region
21 227 SUPERFAMILY SSF54060 His-Me finger endonucleases
21 227 InterPro IPR044925 His-Me finger superfamily
15 19 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
52 231 PANTHER PTHR33607 ENDONUCLEASE-1
52 231 InterPro IPR007346 Endonuclease I
41 227 Pfam PF04231 Endonuclease I
41 227 InterPro IPR007346 Endonuclease I
1 19 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GT48
AlphaFold — — full sequence — Viewing
ColabFold KP13_02729
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.82
2 0.281

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.82 0.088
2 2.0 0.043