Protein profile

KP13_02728

Protein sprT

Genome: KpKP13

Gene: sprT AHE42704.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H2U3
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Amino acids 166
Annotations 0
Features 11
PDB binders 0
Druggability 0.511

Overview

Basic information about this protein and its source genome.

Accession
KP13_02728
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
sprT AHE42704.1
Status
annotated
Amino acids
166
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
47.973
DEG E-value
3.87e-50
Localization
Cytoplasmic
ColabFold pLDDT
95.52

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.511
Structure A0A0H3H2U3
Pocket Pocket 1
P2Rank 0.441
Structure A0A0H3H2U3
Pocket Pocket 1
ColabFold model
FPocket 0.672 · Pocket 2
P2Rank 0.488 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 118 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
12 165 Hamap MF_00746 Protein SprT [sprT].
12 165 InterPro IPR023483 Uncharacterised protein family SprT
20 109 Pfam PF10263 SprT-like family
20 109 InterPro IPR006640 SprT-like
9 163 PANTHER PTHR38773 PROTEIN SPRT
126 162 Pfam PF17283 SprT-like zinc ribbon domain
126 162 InterPro IPR035240 SprT-like, zinc ribbon domain
16 165 SMART SM00731 sprt_6
16 165 InterPro IPR006640 SprT-like
12 120 Gene3D G3DSA:3.30.2010.10 Metalloproteases ("zincins"), catalytic domain
8 35 Coils Coil Coil

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H2U3
AlphaFold — — full sequence — Viewing
ColabFold KP13_02728
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.511
5 0.309
8 0.239
4 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.55 0.441