Protein profile

KP13_05176

insertion element IS1 protein insA

Genome: KpKP13

Gene: AHE42712.1 Structure source: AlphaFold + ColabFold UniProt A0A0F6S075
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Amino acids 91
Annotations 1
Features 5
PDB binders 0
Druggability 0.438

Overview

Basic information about this protein and its source genome.

Accession
KP13_05176
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42712.1
Status
annotated
Amino acids
91
Structure source
AlphaFold + ColabFold
GO
GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
100.0
DEG E-value
3.59e-65
Localization
Unknown
ColabFold pLDDT
88.09

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.438
Structure A0A0F6S075
Pocket Pocket 8
P2Rank 0.003
Structure A0A0F6S075
Pocket Pocket 1
ColabFold model
FPocket 0.456 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 16 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.

Sequence Features

Domain/signature hits from InterPro and related databases.

5 records
Show feature table
Start End DB Term Name
1 91 PANTHER PTHR47923 INSERTION ELEMENT IS1 1 PROTEIN INSA-RELATED
43 88 Pfam PF12759 InsA C-terminal domain
43 88 InterPro IPR024431 Insertion element IS1 protein InsA, helix-turn-helix domain
1 36 Pfam PF03811 InsA N-terminal domain
1 36 InterPro IPR003220 InsA N-terminal domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0F6S075
AlphaFold — — full sequence — Viewing
ColabFold KP13_05176
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.438