Protein profile

KP13_14812

Arginine exporter protein argO

Genome: KpKP13

Gene: ANJ86577.1 argO Structure source: AlphaFold + ColabFold UniProt A0A0H3GSZ1
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Amino acids 211
Annotations 5
Features 27
PDB binders 0
Druggability 0.912

Overview

Basic information about this protein and its source genome.

Accession
KP13_14812
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ANJ86577.1 argO
Status
annotated
Amino acids
211
Structure source
AlphaFold + ColabFold
GO
GO:0061459 Enables the transfer of L-arginine from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:1903826 The directed movement of L-arginine across a membrane. GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
89.1
DEG E-value
4.46e-131
Localization
CytoplasmicMembrane
ColabFold pLDDT
83.46

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.912
Structure A0A0H3GSZ1
Pocket Pocket 11
P2Rank 0.828
Structure A0A0H3GSZ1
Pocket Pocket 1
ColabFold model
FPocket 0.872 · Pocket 1
P2Rank 0.614 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 112 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0061459 Enables the transfer of L-arginine from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:1903826 The directed movement of L-arginine across a membrane.
  • GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

27 records
Show feature table
Start End DB Term Name
182 199 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
67 88 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
15 191 NCBIfam TIGR00948 L-lysine exporter
15 191 InterPro IPR004777 L-lysine exporter/arginine exporter
6 25 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
128 146 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
109 127 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
182 199 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
66 88 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
200 211 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
37 61 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
109 127 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
26 36 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
39 61 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
171 181 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
62 66 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 205 Hamap MF_01901 Arginine exporter protein ArgO [argO].
1 205 InterPro IPR023445 Arginine exporter protein ArgO, enterobacteria
147 169 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
14 201 Pfam PF01810 LysE type translocator
14 201 InterPro IPR001123 Amino acid exporter protein, LeuE-type
147 170 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
4 26 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
89 108 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 205 PANTHER PTHR30086 ARGININE EXPORTER PROTEIN ARGO
1 205 InterPro IPR001123 Amino acid exporter protein, LeuE-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSZ1
AlphaFold — — full sequence — Viewing
ColabFold KP13_14812
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.912
4 0.336
15 0.253

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.24 0.679
2 5.88 0.288
3 0.81 0.003