Protein profile

KP13_02183

hypothetical protein

Genome: KpKP13

Gene: AHE42752.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSX5
Export view
Amino acids 167
Annotations 2
Features 15
PDB binders 4
Druggability 0.282

Overview

Basic information about this protein and its source genome.

Accession
KP13_02183
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42752.1
Status
annotated
Amino acids
167
Structure source
AlphaFold + ColabFold
GO
GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016209 Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
90.3

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.282
Structure A0A0H3GSX5
Pocket Pocket 4
P2Rank 0.025
Structure A0A0H3GSX5
Pocket Pocket 1
ColabFold model
FPocket 0.385 · Pocket 1
P2Rank 0.034 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 60 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
  • GO:0016209 Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
7 156 SUPERFAMILY SSF52833 Thioredoxin-like
7 156 InterPro IPR036249 Thioredoxin-like superfamily
42 163 CDD cd03011 TlpA_like_ScsD_MtbDsbE
32 150 ProSiteProfiles PS51352 Thioredoxin domain profile.
32 150 InterPro IPR013766 Thioredoxin domain
12 20 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region
21 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
40 144 Pfam PF00578 AhpC/TSA family
40 144 InterPro IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
1 11 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
42 158 PANTHER PTHR42852 THIOL:DISULFIDE INTERCHANGE PROTEIN DSBE
12 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
26 167 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
29 158 Gene3D G3DSA:3.40.30.10 Glutaredoxin

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSX5
AlphaFold — — full sequence — Viewing
ColabFold KP13_02183
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.282

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

8 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
C6W
2YP6
A0A0H2UPR5 301.3 Da LogP 1.83 TPSA 58.6 ✓ Ro5 ✓ Clean C[N+](C)(C)CCOP(=O)([O-])OCCCc1ccccc1
HED
4HQZ
A0A0H2UPR5 154.3 Da LogP 0.35 TPSA 40.5 ✓ Ro5 ✓ Clean C(CSSCCO)O
MLI
2YP6
A0A0H2UPR5 102.0 Da LogP -3.12 TPSA 80.3 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(=O)[O-]
PX5
3O6T
P9WG67 243.3 Da LogP 2.18 TPSA 50.2 ✓ Ro5 ✓ Clean c1ccc2c(c1)nc(s2)C3(C=CC(=O)C=C3)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.