Protein profile

KP13_02188

hypothetical protein

Genome: KpKP13

Gene: AHE42757.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSX1
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Amino acids 242
Annotations 5
Features 20
PDB binders 0
Druggability 0.233

Overview

Basic information about this protein and its source genome.

Accession
KP13_02188
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42757.1
Status
annotated
Amino acids
242
Structure source
AlphaFold + ColabFold
GO
GO:1901135 The chemical reactions and pathways involving carbohydrate derivative. GO:0097367 Binding to a carbohydrate derivative. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
91.73

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.233
Structure A0A0H3GSX1
Pocket Pocket 6
P2Rank 0.064
Structure A0A0H3GSX1
Pocket Pocket 1
ColabFold model
FPocket 0.453 · Pocket 10
P2Rank 0.058 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 86 / 4744 genomes with a hit
Normalized 0.018

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:1901135 The chemical reactions and pathways involving carbohydrate derivative.
  • GO:0097367 Binding to a carbohydrate derivative.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
78 242 Gene3D G3DSA:3.40.50.10490 -
99 233 CDD cd05013 SIS_RpiR
99 233 InterPro IPR035472 RpiR-like, SIS domain
33 51 ProSitePatterns PS00356 LacI-type HTH domain signature.
7 239 PANTHER PTHR30514 GLUCOKINASE
7 239 InterPro IPR047640 HTH-type transcriptional regulator RpiR-like
104 240 ProSiteProfiles PS51464 SIS domain profile.
104 240 InterPro IPR001347 SIS domain
110 224 Pfam PF01380 SIS domain
110 224 InterPro IPR001347 SIS domain
86 230 SUPERFAMILY SSF53697 SIS domain
86 230 InterPro IPR046348 SIS domain superfamily
1 73 ProSiteProfiles PS51071 RpiR-type HTH domain profile.
1 73 InterPro IPR000281 Helix-turn-helix protein RpiR
4 77 Gene3D G3DSA:1.10.10.10 -
4 77 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
7 73 SUPERFAMILY SSF46689 Homeodomain-like
7 73 InterPro IPR009057 Homeobox-like domain superfamily
9 71 Pfam PF01418 Helix-turn-helix domain, rpiR family
9 71 InterPro IPR000281 Helix-turn-helix protein RpiR

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSX1
AlphaFold — — full sequence — Viewing
ColabFold KP13_02188
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.233