Protein profile

KP13_02192

hypothetical protein

Genome: KpKP13

Gene: AHE42761.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GY41
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Amino acids 88
Annotations 3
Features 8
PDB binders 0
Druggability 0.752

Overview

Basic information about this protein and its source genome.

Accession
KP13_02192
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42761.1
Status
annotated
Amino acids
88
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0034552 The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II. GO:0006105 The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
88.636
DEG E-value
2.59e-55
Localization
Cytoplasmic
ColabFold pLDDT
91.9

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.752
Structure A0A0H3GY41
Pocket Pocket 1
P2Rank 0.019
Structure A0A0H3GY41
Pocket Pocket 1
ColabFold model
FPocket 0.502 · Pocket 2
P2Rank 0.069 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 125 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0034552 The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II.
  • GO:0006105 The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
1 88 Gene3D G3DSA:1.10.150.250 Flavinator of succinate dehydrogenase
1 88 InterPro IPR036714 Flavinator of succinate dehydrogenase superfamily
1 88 FunFam G3DSA:1.10.150.250:FF:000001 FAD assembly factor SdhE
1 81 PANTHER PTHR39585 FAD ASSEMBLY FACTOR SDHE
1 78 SUPERFAMILY SSF109910 YgfY-like
1 78 InterPro IPR036714 Flavinator of succinate dehydrogenase superfamily
7 79 Pfam PF03937 Flavinator of succinate dehydrogenase
7 79 InterPro IPR005631 Flavinator of succinate dehydrogenase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GY41
AlphaFold — — full sequence — Viewing
ColabFold KP13_02192
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.752