Protein profile

KP13_02194

Flavodoxin-2

Genome: KpKP13

Gene: AHE42763.1 fldB Structure source: AlphaFold + ColabFold UniProt A0A0H3H2L8
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Amino acids 173
Annotations 2
Features 16
PDB binders 5
Druggability 0.279

Overview

Basic information about this protein and its source genome.

Accession
KP13_02194
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42763.1 fldB
Status
annotated
Amino acids
173
Structure source
AlphaFold + ColabFold
GO
GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0010181 Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
43.713
DEG E-value
1.02e-46
Localization
Unknown
ColabFold pLDDT
96.88

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.279
Structure A0A0H3H2L8
Pocket Pocket 3
P2Rank 0.304
Structure A0A0H3H2L8
Pocket Pocket 1
ColabFold model
FPocket 0.443 · Pocket 1
P2Rank 0.339 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 131 / 4744 genomes with a hit
Normalized 0.028

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.
  • GO:0010181 Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
2 168 NCBIfam TIGR01752 flavodoxin
2 168 InterPro IPR010086 Flavodoxin, long chain
3 165 ProSiteProfiles PS50902 Flavodoxin-like domain profile.
3 165 InterPro IPR008254 Flavodoxin/nitric oxide synthase
1 171 PIRSF PIRSF038996 FldA
1 171 InterPro IPR010086 Flavodoxin, long chain
5 160 Pfam PF00258 Flavodoxin
5 160 InterPro IPR008254 Flavodoxin/nitric oxide synthase
1 168 SUPERFAMILY SSF52218 Flavoproteins
1 168 InterPro IPR029039 Flavoprotein-like superfamily
1 170 PANTHER PTHR42809 FLAVODOXIN 2
1 173 Gene3D G3DSA:3.40.50.360 -
1 173 InterPro IPR029039 Flavoprotein-like superfamily
5 21 ProSitePatterns PS00201 Flavodoxin signature.
5 21 InterPro IPR001226 Flavodoxin, conserved site
1 173 FunFam G3DSA:3.40.50.360:FF:000006 Flavodoxin

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H2L8
AlphaFold — — full sequence — Viewing
ColabFold KP13_02194
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.279
7 0.222

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.2 0.171

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

74 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
BTB
1AG9
P61949 209.2 Da LogP -3.01 TPSA 104.4 ✓ Ro5 ✓ Clean C(CO)N(CCO)C(CO)(CO)CO
EN6
6LI0
P00323 489.5 Da LogP 4.22 TPSA 87.4 ✓ Ro5 ✓ Clean Cc1c(c(n(n1)c2cccc3c2sc(c3)Cc4cccc(c4)C(F)(F)F)…
FLC
6LI0
P00323 189.1 Da LogP -5.25 TPSA 140.6 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O
OLC
6LI0
P00323 356.5 Da LogP 4.92 TPSA 66.8 ✓ Ro5 ✓ Clean CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](CO)O
RBF
1BU5
P00323 376.4 Da LogP -1.72 TPSA 161.6 ✓ Ro5 ✓ Clean Cc1cc2c(cc1C)N(C3=NC(=O)NC(=O)C3=N2)C[C@@H]([C@…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.