Protein profile

KP13_02219

Multidrug resistance protein mdtN

Genome: KpKP13

Gene: mdtN AHE42789.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H2J2
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Amino acids 341
Annotations 0
Features 14
PDB binders 0
Druggability 0.43

Overview

Basic information about this protein and its source genome.

Accession
KP13_02219
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
mdtN AHE42789.1
Status
annotated
Amino acids
341
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.15

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.43
Structure A0A0H3H2J2
Pocket Pocket 7
P2Rank 0.009
Structure A0A0H3H2J2
Pocket Pocket 1
ColabFold model
FPocket 0.064 · Pocket 3
P2Rank 0.028 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 26 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
224 340 Gene3D G3DSA:2.40.30.170 -
46 112 SUPERFAMILY SSF111369 HlyD-like secretion proteins
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 35 Phobius SIGNAL_PEPTIDE Signal peptide region
82 113 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
183 295 SUPERFAMILY SSF111369 HlyD-like secretion proteins
48 287 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion
48 287 InterPro IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain
5 340 PANTHER PTHR30367 P-HYDROXYBENZOIC ACID EFFLUX PUMP SUBUNIT AAEA-RELATED
47 81 Gene3D G3DSA:2.40.50.100 -
1 14 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
36 341 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
15 30 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
31 35 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H2J2
AlphaFold — — full sequence — Viewing
ColabFold KP13_02219
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.43