Protein profile

KP13_02222

acyltransferase domain-containing protein

Genome: KpKP13

Gene: AHE42792.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GY18
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Amino acids 90
Annotations 1
Features 10
PDB binders 0
Druggability 0.365

Overview

Basic information about this protein and its source genome.

Accession
KP13_02222
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42792.1
Status
annotated
Amino acids
90
Structure source
AlphaFold + ColabFold
GO
GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
85.556
DEG E-value
1.1099999999999999e-55
Localization
Cytoplasmic
ColabFold pLDDT
97.34

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.365
Structure A0A0H3GY18
Pocket Pocket 1
P2Rank 0.046
Structure A0A0H3GY18
Pocket Pocket 1
ColabFold model
FPocket 0.41 · Pocket 1
P2Rank 0.047 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 66 / 4744 genomes with a hit
Normalized 0.014

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
10 69 CDD cd04301 NAT_SF
1 90 ProSiteProfiles PS51186 Gcn5-related N-acetyltransferase (GNAT) domain profile.
1 90 InterPro IPR000182 GNAT domain
4 88 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
4 88 InterPro IPR016181 Acyl-CoA N-acyltransferase
1 90 Gene3D G3DSA:3.40.630.30 -
2 90 ProSiteProfiles PS51729 Yjdj-type Gcn5-related N-acetyltransferase (GNAT) domain profile.
2 90 InterPro IPR031165 Yjdj-type Gcn5-related N-acetyltransferase
9 88 Pfam PF14542 GCN5-related N-acetyl-transferase
9 88 InterPro IPR031165 Yjdj-type Gcn5-related N-acetyltransferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GY18
AlphaFold — — full sequence — Viewing
ColabFold KP13_02222
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.365

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.48 0.021